biostudies-literatureLiu YYFundamental Research Project of key scientific research in Henan ProvinceNational Natural Science Foundation of ChinaNational Parasitic Resources Center, and the Ministry of Science and Technology fund371https://www.ebi.ac.uk/biostudies/studies/S-EPMC11366163biostudies-literatureUnknown17(1)<h4>Background</h4>Plerocercoid larvae of the tapeworm Spirometra mansoni can infect both humans and animals, leading to severe parasitic zoonosis worldwide. Despite ongoing research efforts, our understanding of the developmental process of S. mansoni remains inadequate. To better characterize posttranslational regulation associated with parasite growth, development, and reproduction, a comparative phosphoproteomic study was conducted on the plerocercoid and adult stages of S. mansoni.<h4>Methods</h4>In this study, site-specific phosphoproteomic analysis was conducted via 4D label-free quantitative analysis technology to obtain primary information about the overall phosphorylation status of plerocercoids and adults.<h4>Results</h4>A total of 778 differentially abundant proteins (DAPs) werParasites & vectorsComparative analysis of phosphorylated proteomes between plerocercoid and adult Spirometra mansoni reveals phosphoproteomic profiles of the medical tapeworm.PMC1136616324ZX003NPRC-2019-194-3081971956Wang RJRu SSLiu YYZhang XGao FLiu WfalseComparative analysis of phosphorylated proteomes between plerocercoid and adult Spirometra mansoni reveals phosphoproteomic profiles of the medical tapeworm.<h4>Background</h4>Plerocercoid larvae of the tapeworm Spirometra mansoni can infect both humans and animals, leading to severe parasitic zoonosis worldwide. Despite ongoing research efforts, our understanding of the developmental process of S. mansoni remains inadequate. To better characterize posttranslational regulation associated with parasite growth, development, and reproduction, a comparative phosphoproteomic study was conducted on the plerocercoid and adult stages of S. mansoni.<h4>Methods</h4>In this study, site-specific phosphoproteomic analysis was conducted via 4D label-free quantitative analysis technology to obtain primary information about the overall phosphorylation status of plerocercoids and adults.<h4>Results</h4>A total of 778 differentially abundant proteins (DAPs) wer2024-01-01T00:00:00Z2024 Aug2026-06-01T19:47:21.749Z2025-04-04T10:39:12.96ZS-EPMC113661633921735910.1186/s13071-024-06454-8