{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Juli MSB"],"pubmed_abstract":["<h4>Background</h4>Bovine genital campylobacteriosis (BGC) is a globally important venereal disease of cattle caused by <i>Campylobacter fetus</i> subspecies <i>venerealis</i>. Diagnosis of BGC is highly challenging due to the lack of accurate diagnostic tests.<h4>Methods</h4>To characterise the biomarkers for <i>C. fetus venerealis</i> infection, a total of twelve cycling heifers were selected and categorised as vaccinated (<i>n</i> = 6) with Vibrovax® (Zoetis™) and unvaccinated (<i>n</i> = 6). All heifers were oestrous synchronised with a double dose of prostaglandin (PGF2α) 11 days apart and when in oestrous intravaginally challenged with 2.7 x 10<sup>9</sup> CFU live <i>C. fetus venerealis</i>. DNA extracted from vaginal mucus samples was screened using a <i>C. fetus</i> qPCR and 16S r"],"journal":["Frontiers in microbiology"],"pagination":["1404525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11366586"],"repository":["biostudies-literature"],"pubmed_title":["Characterisation of reproductive tract microbiome and immune biomarkers for bovine genital campylobacteriosis in vaccinated and unvaccinated heifers."],"pmcid":["PMC11366586"],"pubmed_authors":["Siddle HV","Boe-Hansen GB","Forutan M","Juli MSB","Tabor AE","Raza A","Fordyce G","Muller J"],"additional_accession":[]},"is_claimable":false,"name":"Characterisation of reproductive tract microbiome and immune biomarkers for bovine genital campylobacteriosis in vaccinated and unvaccinated heifers.","description":"<h4>Background</h4>Bovine genital campylobacteriosis (BGC) is a globally important venereal disease of cattle caused by <i>Campylobacter fetus</i> subspecies <i>venerealis</i>. Diagnosis of BGC is highly challenging due to the lack of accurate diagnostic tests.<h4>Methods</h4>To characterise the biomarkers for <i>C. fetus venerealis</i> infection, a total of twelve cycling heifers were selected and categorised as vaccinated (<i>n</i> = 6) with Vibrovax® (Zoetis™) and unvaccinated (<i>n</i> = 6). All heifers were oestrous synchronised with a double dose of prostaglandin (PGF2α) 11 days apart and when in oestrous intravaginally challenged with 2.7 x 10<sup>9</sup> CFU live <i>C. fetus venerealis</i>. DNA extracted from vaginal mucus samples was screened using a <i>C. fetus</i> qPCR and 16S r","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T16:15:06.849Z","creation":"2024-11-15T04:43:34.081Z"},"accession":"S-EPMC11366586","cross_references":{"pubmed":["39224219"],"doi":["10.3389/fmicb.2024.1404525"]}}