{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["109(9)"],"submitter":["Oostenbrink LVE"],"pubmed_abstract":["Anti-T-lymphocyte globulin (ATLG) is used in hematopoietic stem cell transplantation (HSCT) to prevent graft-versus-host disease (GVHD) and graft failure. To date, insight in ATLG pharmacokinetics and -dynamics (PK/PD) is limited, and population PK (POPPK) models are lacking. In this prospective study, we describe ATLG POPPK using NONMEM® and the impact of ATLG exposure on clinical outcome and immune reconstitution in a homogeneous cohort of pediatric acute lymphoblastic leukemia (ALL) patients transplanted with a matched unrelated donor and receiving uniform ATLG dosing. Based on 121 patients and 812 samples for POPPK analysis, a two-compartmental model with parallel linear and non-linear clearance and bodyweight as covariate, best described the ATLG concentration-time data. The level of "],"journal":["Haematologica"],"pagination":["2854-2863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11367195"],"repository":["biostudies-literature"],"pubmed_title":["Anti-T-lymphocyte globulin exposure is associated with acute graft-<i>versus</i>-host disease and relapse in pediatric acute lymphoblastic leukemia patients undergoing hematopoietic stem cell transplantation: a multinational prospective study."],"pmcid":["PMC11367195"],"pubmed_authors":["Peters C","Ifversen M","Vervat C","Schilham MW","Jol-van der Zijde CM","Lankester AC","Bredius RGM","Moes DJAR","Balduzzi A","Bader P","Oostenbrink LVE","Von Asmuth EGJ","Jansen-Hoogendijk AM","Van Tol MJD","Sedlacek P"],"additional_accession":[]},"is_claimable":false,"name":"Anti-T-lymphocyte globulin exposure is associated with acute graft-<i>versus</i>-host disease and relapse in pediatric acute lymphoblastic leukemia patients undergoing hematopoietic stem cell transplantation: a multinational prospective study.","description":"Anti-T-lymphocyte globulin (ATLG) is used in hematopoietic stem cell transplantation (HSCT) to prevent graft-versus-host disease (GVHD) and graft failure. To date, insight in ATLG pharmacokinetics and -dynamics (PK/PD) is limited, and population PK (POPPK) models are lacking. In this prospective study, we describe ATLG POPPK using NONMEM® and the impact of ATLG exposure on clinical outcome and immune reconstitution in a homogeneous cohort of pediatric acute lymphoblastic leukemia (ALL) patients transplanted with a matched unrelated donor and receiving uniform ATLG dosing. Based on 121 patients and 812 samples for POPPK analysis, a two-compartmental model with parallel linear and non-linear clearance and bodyweight as covariate, best described the ATLG concentration-time data. The level of ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-07-15T12:01:09.205Z","creation":"2026-07-04T03:12:11.794Z"},"accession":"S-EPMC11367195","cross_references":{"pubmed":["38721739"],"doi":["10.3324/haematol.2023.284632"]}}