biostudies-literatureUnknown109(9)Oostenbrink LVEAnti-T-lymphocyte globulin (ATLG) is used in hematopoietic stem cell transplantation (HSCT) to prevent graft-versus-host disease (GVHD) and graft failure. To date, insight in ATLG pharmacokinetics and -dynamics (PK/PD) is limited, and population PK (POPPK) models are lacking. In this prospective study, we describe ATLG POPPK using NONMEM® and the impact of ATLG exposure on clinical outcome and immune reconstitution in a homogeneous cohort of pediatric acute lymphoblastic leukemia (ALL) patients transplanted with a matched unrelated donor and receiving uniform ATLG dosing. Based on 121 patients and 812 samples for POPPK analysis, a two-compartmental model with parallel linear and non-linear clearance and bodyweight as covariate, best described the ATLG concentration-time data. The level of Haematologica2854-2863https://www.ebi.ac.uk/biostudies/studies/S-EPMC11367195biostudies-literatureAnti-T-lymphocyte globulin exposure is associated with acute graft-<i>versus</i>-host disease and relapse in pediatric acute lymphoblastic leukemia patients undergoing hematopoietic stem cell transplantation: a multinational prospective study.PMC11367195Peters CIfversen MVervat CSchilham MWJol-van der Zijde CMLankester ACBredius RGMMoes DJARBalduzzi ABader POostenbrink LVEVon Asmuth EGJJansen-Hoogendijk AMVan Tol MJDSedlacek PfalseAnti-T-lymphocyte globulin exposure is associated with acute graft-<i>versus</i>-host disease and relapse in pediatric acute lymphoblastic leukemia patients undergoing hematopoietic stem cell transplantation: a multinational prospective study.Anti-T-lymphocyte globulin (ATLG) is used in hematopoietic stem cell transplantation (HSCT) to prevent graft-versus-host disease (GVHD) and graft failure. To date, insight in ATLG pharmacokinetics and -dynamics (PK/PD) is limited, and population PK (POPPK) models are lacking. In this prospective study, we describe ATLG POPPK using NONMEM® and the impact of ATLG exposure on clinical outcome and immune reconstitution in a homogeneous cohort of pediatric acute lymphoblastic leukemia (ALL) patients transplanted with a matched unrelated donor and receiving uniform ATLG dosing. Based on 121 patients and 812 samples for POPPK analysis, a two-compartmental model with parallel linear and non-linear clearance and bodyweight as covariate, best described the ATLG concentration-time data. The level of 2024-01-01T00:00:00Z2024 Sep2026-07-15T12:01:09.205Z2026-07-04T03:12:11.794ZS-EPMC113671953872173910.3324/haematol.2023.284632