biostudies-literatureUnknown10(3)Luciano J<h4>Objectives</h4>The association between immune-mediated thrombotic thrombocytopenic purpura (iTTP) and Sjögren disease (SjD) has been poorly investigated. This study presents the first retrospective cohort of iTTP-SjD aiming to identify risk factors for iTTP occurrence in SjD patients and examine their clinical course.<h4>Methods</h4>Patients with iTTP-SjD were identified within the French TTP Registry based on American College of Rheumatology/European League Against Rheumatism 2016 criteria. A comparative analysis was conducted with two control groups comprising primary SjD (pSjD) patients from the French ASSESS cohort and idiopathic iTTP patients from the French TTP Registry. Demographic, clinical and biological data were retrospectively collected.<h4>Results</h4>Thirty iTTP-SjD patieRMD opene004426https://www.ebi.ac.uk/biostudies/studies/S-EPMC11367322biostudies-literatureClinical, biological, prognostic characteristics of patients with immune-mediated thrombotic thrombocytopenic purpura and Sjogren's disease.PMC11367322Bonnet ILuciano JVeyradier AMariette XNocturne GCoppo PGilardin LBouzid RJoly BSfalseClinical, biological, prognostic characteristics of patients with immune-mediated thrombotic thrombocytopenic purpura and Sjogren's disease.<h4>Objectives</h4>The association between immune-mediated thrombotic thrombocytopenic purpura (iTTP) and Sjögren disease (SjD) has been poorly investigated. This study presents the first retrospective cohort of iTTP-SjD aiming to identify risk factors for iTTP occurrence in SjD patients and examine their clinical course.<h4>Methods</h4>Patients with iTTP-SjD were identified within the French TTP Registry based on American College of Rheumatology/European League Against Rheumatism 2016 criteria. A comparative analysis was conducted with two control groups comprising primary SjD (pSjD) patients from the French ASSESS cohort and idiopathic iTTP patients from the French TTP Registry. Demographic, clinical and biological data were retrospectively collected.<h4>Results</h4>Thirty iTTP-SjD patie2024-01-01T00:00:00Z2024 Aug2025-04-22T13:07:46.683Z2024-11-06T23:25:15.489ZS-EPMC113673223920972810.1136/rmdopen-2024-004426