{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["Beijing Agriculture Innovation Consortium","National Key Research and Development Program of China"],"pagination":["997-1007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11368200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(7)"],"pubmed_abstract":["We present the first chromosome-level genome assembly of the grasshopper, <i>Locusta migratoria</i>, one of the largest insect genomes. We use coverage differences between females (XX) and males (X0) to identify the X Chromosome gene content, and find that the X Chromosome shows both complete dosage compensation in somatic tissues and an underrepresentation of testis-expressed genes. X-linked gene content from <i>L. migratoria</i> is highly conserved across seven insect orders, namely Orthoptera, Odonata, Phasmatodea, Hemiptera, Neuroptera, Coleoptera, and Diptera, and the 800 Mb grasshopper X Chromosome is homologous to the fly ancestral X Chromosome despite 400 million years of divergence, suggesting either repeated origin of sex chromosomes with highly similar gene content, or long-term conservation of the X Chromosome. We use this broad conservation of the X Chromosome to test for temporal dynamics to Fast-X evolution, and find evidence of a recent burst evolution for new X-linked genes in contrast to slow evolution of X-conserved genes."],"journal":["Genome research"],"pubmed_title":["The grasshopper genome reveals long-term gene content conservation of the X Chromosome and temporal variation in X Chromosome evolution."],"pmcid":["PMC11368200"],"funding_grant_id":["BAIC02-2022"],"pubmed_authors":["Li X","Ban L","Mank JE"],"additional_accession":[]},"is_claimable":false,"name":"The grasshopper genome reveals long-term gene content conservation of the X Chromosome and temporal variation in X Chromosome evolution.","description":"We present the first chromosome-level genome assembly of the grasshopper, <i>Locusta migratoria</i>, one of the largest insect genomes. We use coverage differences between females (XX) and males (X0) to identify the X Chromosome gene content, and find that the X Chromosome shows both complete dosage compensation in somatic tissues and an underrepresentation of testis-expressed genes. X-linked gene content from <i>L. migratoria</i> is highly conserved across seven insect orders, namely Orthoptera, Odonata, Phasmatodea, Hemiptera, Neuroptera, Coleoptera, and Diptera, and the 800 Mb grasshopper X Chromosome is homologous to the fly ancestral X Chromosome despite 400 million years of divergence, suggesting either repeated origin of sex chromosomes with highly similar gene content, or long-term conservation of the X Chromosome. We use this broad conservation of the X Chromosome to test for temporal dynamics to Fast-X evolution, and find evidence of a recent burst evolution for new X-linked genes in contrast to slow evolution of X-conserved genes.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-02T06:48:56.938Z","creation":"2026-04-15T03:15:31.979Z"},"accession":"S-EPMC11368200","cross_references":{"pubmed":["39103228"],"doi":["10.1101/gr.278794.123"]}}