{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu YH"],"funding":["Indiana University","NIDA NIH HHS","National Institute on Drug Abuse"],"pagination":["1438-1448"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11368633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(10)"],"pubmed_abstract":["The goal of this study is to investigate the association between chronic non-cancer pain (CNCP) and mild cognitive impairment (MCI)/Alzheimer's disease and related dementias (ADRDs) development among adults aged ≥50 using administrative claims data from a national commercial health insurance company during 2007-2017. To reduce selection bias, propensity-score matching was applied to select comparable CNCP and non-CNCP patients. Time-dependent Cox proportional-hazards regressions were conducted to estimate the hazard ratios (HRs) of incident MCI/ADRDs. Of 170,900 patients with/without CNCP, 0.61% developed MCI and 2.33% had been diagnosed with ADRDs during the follow-up period. Controlling for potential confounders, CNCP patients had a 123% increase in MCI risk (HR = 2.23; 95% CI = 1.92-2.5"],"journal":["Journal of applied gerontology : the official journal of the Southern Gerontological Society"],"pubmed_title":["Chronic Non-cancer Pain and Associated Risks of Incident Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias in Middle-Aged and Older Adults."],"pmcid":["PMC11368633"],"funding_grant_id":["Addictions Grand Challenge Initiative","R01 DA039928"],"pubmed_authors":["Lin HC","Huber L","Seo DC","Shih PC","Hu YH"],"additional_accession":[]},"is_claimable":false,"name":"Chronic Non-cancer Pain and Associated Risks of Incident Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias in Middle-Aged and Older Adults.","description":"The goal of this study is to investigate the association between chronic non-cancer pain (CNCP) and mild cognitive impairment (MCI)/Alzheimer's disease and related dementias (ADRDs) development among adults aged ≥50 using administrative claims data from a national commercial health insurance company during 2007-2017. To reduce selection bias, propensity-score matching was applied to select comparable CNCP and non-CNCP patients. Time-dependent Cox proportional-hazards regressions were conducted to estimate the hazard ratios (HRs) of incident MCI/ADRDs. Of 170,900 patients with/without CNCP, 0.61% developed MCI and 2.33% had been diagnosed with ADRDs during the follow-up period. Controlling for potential confounders, CNCP patients had a 123% increase in MCI risk (HR = 2.23; 95% CI = 1.92-2.5","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-05T18:42:39.422Z","creation":"2025-04-05T18:42:39.422Z"},"accession":"S-EPMC11368633","cross_references":{"pubmed":["38451267"],"doi":["10.1177/07334648241237340"]}}