{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moylan AD"],"funding":["NIDCR NIH HHS","NIH/NIDCR","NCI NIH HHS"],"pagination":["354-367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11368658"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(5)"],"pubmed_abstract":["Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown. Bis-(3'-5') cyclic diadenosine monophosphate (c-di-AMP) is a nucleotide secondary messenger that regulates osmolyte transport, central metabolism, biofilm development, and pathogenicity in many bacteria but is uncharacterized in T. denticola. Here, we studied c-di-AMP signaling in T. denticola to understand how it contributes to T. denticola physiology. We demonstrated that T. denticola produces c-di-AMP and identified enzymes that function in the synthesis (TDE1909) and hydrolysis (TD"],"journal":["Molecular oral microbiology"],"pubmed_title":["Characterization of c-di-AMP signaling in the periodontal pathobiont, Treponema denticola."],"pmcid":["PMC11368658"],"funding_grant_id":["R00 DE028346","P30 CA016059","R00DE028346"],"pubmed_authors":["Marconi RT","Miller DP","O'Brien C","Patel DT","Schuler EJA","Hinson AN","Moylan AD"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of c-di-AMP signaling in the periodontal pathobiont, Treponema denticola.","description":"Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown. Bis-(3'-5') cyclic diadenosine monophosphate (c-di-AMP) is a nucleotide secondary messenger that regulates osmolyte transport, central metabolism, biofilm development, and pathogenicity in many bacteria but is uncharacterized in T. denticola. Here, we studied c-di-AMP signaling in T. denticola to understand how it contributes to T. denticola physiology. We demonstrated that T. denticola produces c-di-AMP and identified enzymes that function in the synthesis (TDE1909) and hydrolysis (TD","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-04T01:38:56.9Z","creation":"2026-05-04T03:12:22.376Z"},"accession":"S-EPMC11368658","cross_references":{"pubmed":["38436552"],"doi":["10.1111/omi.12458"]}}