{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Tao R"],"pubmed_abstract":["<h4>Objective</h4>Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (<i>VDR</i>) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between <i>VDR</i> polymorphisms and TB susceptibility.<h4>Methods</h4>We systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (<i>OR</i>) and 95% confidence interval (<i>CI</i>) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle-Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses.<h4>Results</h4>In our meta-analysis, we found that the FokI polymorphism in the <i>VDR</i> gene was associated with increased TB susceptibility in the allele and recessive genotype models (<i>OR</i> f vs. F = 1.235, 95%<i>CI</i>: 1.035-1.475; <i>OR</i> ff vs. Ff + FF = 1.317, 95%<i>CI</i>: 1.005-1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the <i>VDR</i> gene. However, publication year was another source of heterogeneity for the <i>Taq</i>I polymorphism.<h4>Conclusion</h4>In summary, the <i>Fok</i>I polymorphism in the <i>VDR</i> gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health."],"journal":["Frontiers in genetics"],"pagination":["1382957"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11368754"],"repository":["biostudies-literature"],"pubmed_title":["Association between vitamin D receptor gene polymorphisms and susceptibility to tuberculosis: a systematic review and meta-analysis."],"pmcid":["PMC11368754"],"pubmed_authors":["Liu H","Hu C","Luo W","Tao R","Hong F","Li Q","Xiao S","Suo H","Zhao J","Long R","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Association between vitamin D receptor gene polymorphisms and susceptibility to tuberculosis: a systematic review and meta-analysis.","description":"<h4>Objective</h4>Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (<i>VDR</i>) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between <i>VDR</i> polymorphisms and TB susceptibility.<h4>Methods</h4>We systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (<i>OR</i>) and 95% confidence interval (<i>CI</i>) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle-Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses.<h4>Results</h4>In our meta-analysis, we found that the FokI polymorphism in the <i>VDR</i> gene was associated with increased TB susceptibility in the allele and recessive genotype models (<i>OR</i> f vs. F = 1.235, 95%<i>CI</i>: 1.035-1.475; <i>OR</i> ff vs. Ff + FF = 1.317, 95%<i>CI</i>: 1.005-1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the <i>VDR</i> gene. However, publication year was another source of heterogeneity for the <i>Taq</i>I polymorphism.<h4>Conclusion</h4>In summary, the <i>Fok</i>I polymorphism in the <i>VDR</i> gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-21T03:19:47.274Z","creation":"2025-04-07T12:59:38.873Z"},"accession":"S-EPMC11368754","cross_references":{"pubmed":["39228416"],"doi":["10.3389/fgene.2024.1382957"]}}