biostudies-literatureUnknown15Tao R<h4>Objective</h4>Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (<i>VDR</i>) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between <i>VDR</i> polymorphisms and TB susceptibility.<h4>Methods</h4>We systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (<i>OR</i>) and 95% confidence interval (<i>CI</i>) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle-Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses.<h4>Results</h4>In our meta-analysis, we found that the FokI polymorphism in the <i>VDR</i> gene was associated with increased TB susceptibility in the allele and recessive genotype models (<i>OR</i> f vs. F = 1.235, 95%<i>CI</i>: 1.035-1.475; <i>OR</i> ff vs. Ff + FF = 1.317, 95%<i>CI</i>: 1.005-1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the <i>VDR</i> gene. However, publication year was another source of heterogeneity for the <i>Taq</i>I polymorphism.<h4>Conclusion</h4>In summary, the <i>Fok</i>I polymorphism in the <i>VDR</i> gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health.Frontiers in genetics1382957https://www.ebi.ac.uk/biostudies/studies/S-EPMC11368754biostudies-literatureAssociation between vitamin D receptor gene polymorphisms and susceptibility to tuberculosis: a systematic review and meta-analysis.PMC11368754Liu HHu CLuo WTao RHong FLi QXiao SSuo HZhao JLong RWang LfalseAssociation between vitamin D receptor gene polymorphisms and susceptibility to tuberculosis: a systematic review and meta-analysis.<h4>Objective</h4>Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (<i>VDR</i>) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between <i>VDR</i> polymorphisms and TB susceptibility.<h4>Methods</h4>We systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (<i>OR</i>) and 95% confidence interval (<i>CI</i>) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle-Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses.<h4>Results</h4>In our meta-analysis, we found that the FokI polymorphism in the <i>VDR</i> gene was associated with increased TB susceptibility in the allele and recessive genotype models (<i>OR</i> f vs. F = 1.235, 95%<i>CI</i>: 1.035-1.475; <i>OR</i> ff vs. Ff + FF = 1.317, 95%<i>CI</i>: 1.005-1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the <i>VDR</i> gene. However, publication year was another source of heterogeneity for the <i>Taq</i>I polymorphism.<h4>Conclusion</h4>In summary, the <i>Fok</i>I polymorphism in the <i>VDR</i> gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health.2024-01-01T00:00:00Z20242026-05-21T03:19:47.274Z2025-04-07T12:59:38.873ZS-EPMC113687543922841610.3389/fgene.2024.1382957