biostudies-literatureUnknownHaas RNCI NIH HHSNIGMS NIH HHSMultifocal prostate cancer is a prevalent phenomenon, with most cases remaining uncharacterized from a genomic perspective. A patient presented with bilateral prostate cancer. On systematic biopsy, two indistinguishable clinicopathologic lesions were detected. Whole-genome sequencing displayed somatically unrelated tumours with distinct driver CNA regions, suggesting independent origins of the two tumors. We demonstrated that similar clinicopathologic multifocal tumours, which might be interpreted as clonal disease, can in fact represent independent cancers. Genetic prognostics can prevent mischaracterization of multifocal disease to enable optimal patient management.medRxiv : the preprint server for health sciences2024.08.22.24312320https://www.ebi.ac.uk/biostudies/studies/S-EPMC11370525biostudies-literatureDivergent Evolution in Bilateral Prostate Cancer: a Case Study.PMC11370525R01 CA270108T32 GM008042P30 CA016042U2C CA271894P50 CA092131Huang RRWeiner ALiu LYBoutros PCPatel YYamaguchi TNHaas RReiter REAgrawal RfalseDivergent Evolution in Bilateral Prostate Cancer: a Case Study.Multifocal prostate cancer is a prevalent phenomenon, with most cases remaining uncharacterized from a genomic perspective. A patient presented with bilateral prostate cancer. On systematic biopsy, two indistinguishable clinicopathologic lesions were detected. Whole-genome sequencing displayed somatically unrelated tumours with distinct driver CNA regions, suggesting independent origins of the two tumors. We demonstrated that similar clinicopathologic multifocal tumours, which might be interpreted as clonal disease, can in fact represent independent cancers. Genetic prognostics can prevent mischaracterization of multifocal disease to enable optimal patient management.2024-01-01T00:00:00Z2024 Aug2025-04-18T13:08:32.449Z2025-04-06T22:39:20.909ZS-EPMC113705253922874110.1101/2024.08.22.24312320