biostudies-literatureUnknownMD Anderson Head and Neck Symptom Working GroupNIDCR NIH HHSNCATS NIH HHSNCI NIH HHSZonMw<h4>Background</h4>Existing studies on osteoradionecrosis of the jaw (ORNJ) have primarily used cross-sectional data, assessing risk factors at a single time point. Determining the time-to-event profile of ORNJ has important implications to monitor oral health in head and neck cancer (HNC) long-term survivors.<h4>Methods</h4>Demographic, clinical and dosimetric data were retrospectively obtained for a clinical observational cohort of 1129 patients with HNC treated with radiotherapy (RT) at The University of Texas MD Anderson Cancer Center. ORNJ was diagnosed in 198 patients (18%). A multivariable logistic regression analysis with forward stepwise variable selection identified significant predictors for ORNJ. These predictors were then used to train a Weibull Accelerated Failure Time (AFT) medRxiv : the preprint server for health sciences2024.08.20.24312311https://www.ebi.ac.uk/biostudies/studies/S-EPMC11370531biostudies-literatureMandibular dose-volume predicts time-to-osteoradionecrosis in an actuarial normal-tissue complication probability (NTCP) model: External validation of right-censored clinico-dosimetric and competing risk application across international multi-institutional observational cohorts and online graphical user interface clinical support tool assessment.PMC11370531R01 DE028290R03 DE033550U01 DE032168K01 DE03052409150162010173R01 CA257814T32 CA261856P30 CA016672R01 CA258827R01 DE025248R21 DE031082K12 CA088084UG3 TR004501Mohamed ASRWest NAPhan JWahid KAHosseinian SWentzel AHope AWatson EOtun AOLee AMoreno ACRosenthal DFrank SJCollaborators:Brock KKMorrison WHMarai GEUrbano TGCanahuate Gvan Dijk LVSchaefer AJGarden ASLai SYMD Anderson Head and Neck Symptom Working GroupChen MMPatel VSandulache VCFuller CDKaffey ZAponte-Wesson RHutcheson KASpiotto MTHe RHumbert-Vidan LSpier KBZhang XRigert JKamel SAbdelaal MChambers MNaser MAfalseMandibular dose-volume predicts time-to-osteoradionecrosis in an actuarial normal-tissue complication probability (NTCP) model: External validation of right-censored clinico-dosimetric and competing risk application across international multi-institutional observational cohorts and online graphical user interface clinical support tool assessment.<h4>Background</h4>Existing studies on osteoradionecrosis of the jaw (ORNJ) have primarily used cross-sectional data, assessing risk factors at a single time point. Determining the time-to-event profile of ORNJ has important implications to monitor oral health in head and neck cancer (HNC) long-term survivors.<h4>Methods</h4>Demographic, clinical and dosimetric data were retrospectively obtained for a clinical observational cohort of 1129 patients with HNC treated with radiotherapy (RT) at The University of Texas MD Anderson Cancer Center. ORNJ was diagnosed in 198 patients (18%). A multivariable logistic regression analysis with forward stepwise variable selection identified significant predictors for ORNJ. These predictors were then used to train a Weibull Accelerated Failure Time (AFT) 2024-01-01T00:00:00Z2024 Aug2025-04-18T22:41:19.079Z2025-04-07T10:27:51.451ZS-EPMC113705313922872410.1101/2024.08.20.24312311