{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Mariniello K"],"funding":["NIDDK NIH HHS","Biotechnology and Biological Sciences Research Council"],"pubmed_abstract":["Disruption of processes involved in tissue development and homeostatic self-renewal is increasingly implicated in cancer initiation, progression, and recurrence. The adrenal cortex is a dynamic tissue that undergoes life-long turnover. Here, using genetic fate mapping and murine adrenocortical carcinoma (ACC) models, we have identified a population of adrenocortical stem cells that express delta-like non-canonical Notch ligand 1 (DLK1). These cells are active during development, near dormant postnatally but are re-expressed in ACC. In a study of over 200 human ACC samples, we have shown DLK1 expression is ubiquitous and is an independent prognostic marker of recurrence-free survival. Paradoxically, despite its progenitor role, spatial transcriptomic analysis has identified DLK1 expressing "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.08.22.609117"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11370565"],"repository":["biostudies-literature"],"pubmed_title":["Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma."],"pmcid":["PMC11370565"],"funding_grant_id":["BB/V007246/1","R01 DK123694"],"pubmed_authors":["Tamburello M","Pittaway JFH","Palazzo F","Ronchi CL","Sigala S","Kroiss M","Abdel-Aziz TE","Parvanta L","Lim JA","Ruiz-Babot G","Doroszko M","Foster J","Rayner O","Breault DT","Guasti L","Altieri B","Hadjidemetriou I","Gaston-Massuet C","Wierman M","Gomez-Sanchez CE","Di Marco A","Drake WM","Borges KS","Chung TT","Rahman N","Ribeiro C","Abate A","Kiseljak-Vassiliades K","Mariniello K","Hantel C","Sosabowski J","Fassnacht M","Sbiera S","Cleaver J","Taylor DR","Rognoni E"],"additional_accession":[]},"is_claimable":false,"name":"Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma.","description":"Disruption of processes involved in tissue development and homeostatic self-renewal is increasingly implicated in cancer initiation, progression, and recurrence. The adrenal cortex is a dynamic tissue that undergoes life-long turnover. Here, using genetic fate mapping and murine adrenocortical carcinoma (ACC) models, we have identified a population of adrenocortical stem cells that express delta-like non-canonical Notch ligand 1 (DLK1). These cells are active during development, near dormant postnatally but are re-expressed in ACC. In a study of over 200 human ACC samples, we have shown DLK1 expression is ubiquitous and is an independent prognostic marker of recurrence-free survival. Paradoxically, despite its progenitor role, spatial transcriptomic analysis has identified DLK1 expressing ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-22T20:51:24.296Z","creation":"2025-04-06T03:20:40.962Z"},"accession":"S-EPMC11370565","cross_references":{"pubmed":["39229217"],"doi":["10.1101/2024.08.22.609117"]}}