{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["NINDS NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["2991-2997"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11370786"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["147(9)"],"pubmed_abstract":["Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in patients suffering from this largely untreated disease. While many intracellular signalling mechanisms have been examined in preclinical models that drive spontaneous activity, none have been tested directly on spontaneously active human nociceptors. Using cultured DRG neurons recovered during thoracic vertebrectomy surgeries, we showed that inhibition of mitogen-activated protein kinase interacting kinase (MNK) with tomivosertib (eFT508, 25 nM) reversibly suppresses spontaneous activity in human sensory neurons that are likely nociceptors based on size and action potential characteristics associated with painful dermatomes within minutes of treatment. Tomivosertib treatment also decreased act"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Tomivosertib reduces ectopic activity in dorsal root ganglion neurons from patients with radiculopathy."],"pmcid":["PMC11370786"],"funding_grant_id":["R01 NS065926","R01NS111929","K00 NS120636","K00NS120636","U19 NS130608","U19NS130608","R01NS065926","R01 NS111929"],"pubmed_authors":["Uhelski ML","Li Y","McDonough KE","Corrales G","Dussor G","Tatsui CE","Dougherty PM","North RY","Mwirigi JM","Cata JP","Price TJ"],"additional_accession":[]},"is_claimable":false,"name":"Tomivosertib reduces ectopic activity in dorsal root ganglion neurons from patients with radiculopathy.","description":"Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in patients suffering from this largely untreated disease. While many intracellular signalling mechanisms have been examined in preclinical models that drive spontaneous activity, none have been tested directly on spontaneously active human nociceptors. Using cultured DRG neurons recovered during thoracic vertebrectomy surgeries, we showed that inhibition of mitogen-activated protein kinase interacting kinase (MNK) with tomivosertib (eFT508, 25 nM) reversibly suppresses spontaneous activity in human sensory neurons that are likely nociceptors based on size and action potential characteristics associated with painful dermatomes within minutes of treatment. Tomivosertib treatment also decreased act","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-08-14T03:06:00.477Z","creation":"2025-08-14T03:06:00.477Z"},"accession":"S-EPMC11370786","cross_references":{"pubmed":["39046204"],"doi":["10.1093/brain/awae178"]}}