biostudies-literatureKhidir SJHEuropean Research CouncilEuropean Union’s Horizon 2020European Union's Horizon 20202336-2344https://www.ebi.ac.uk/biostudies/studies/S-EPMC11371371biostudies-literatureUnknown63(9)<h4>Objectives</h4>ACPA-positive and ACPA-negative RA differ in underlying risk factors but have a similar clinical presentation at RA diagnosis. It is unknown what the ACPA-associated differences or similarities are during the symptomatic at-risk stage of RA, i.e. clinically suspect arthralgia (CSA). To deepen insights into these differences/similarities, we compared the course of symptoms/impairments and subclinical joint inflammation in the CSA phase during progression to inflammatory arthritis (IA) or to CSA resolution.<h4>Methods</h4>A total of 845 CSA patients were followed for a median of 24 months; 136 patients developed IA and an additional 355/505 patients had resolution of CSA according to rheumatologists. Patient burden (pain, morning stiffness, fatigue, functional disabilitiesRheumatology (Oxford, England)Patient burden and joint inflammation during development of RA from arthralgia: is it similar in ACPA-positive and ACPA-negative disease?PMC11371371714312van Mulligen Evan der Helm-van Mil AHMKrijbolder DIKhidir SJHGlas HKfalsePatient burden and joint inflammation during development of RA from arthralgia: is it similar in ACPA-positive and ACPA-negative disease?<h4>Objectives</h4>ACPA-positive and ACPA-negative RA differ in underlying risk factors but have a similar clinical presentation at RA diagnosis. It is unknown what the ACPA-associated differences or similarities are during the symptomatic at-risk stage of RA, i.e. clinically suspect arthralgia (CSA). To deepen insights into these differences/similarities, we compared the course of symptoms/impairments and subclinical joint inflammation in the CSA phase during progression to inflammatory arthritis (IA) or to CSA resolution.<h4>Methods</h4>A total of 845 CSA patients were followed for a median of 24 months; 136 patients developed IA and an additional 355/505 patients had resolution of CSA according to rheumatologists. Patient burden (pain, morning stiffness, fatigue, functional disabilities2024-01-01T00:00:00Z2024 Sep2026-05-08T20:08:12.461Z2025-02-19T02:34:49.09ZS-EPMC113713713826162810.1093/rheumatology/keae044