{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang H"],"funding":["National Key Research and Development Program","National Natural Science Foundation of China"],"pagination":["20519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11371808"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly incr"],"journal":["Scientific reports"],"pubmed_title":["Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19."],"pmcid":["PMC11371808"],"funding_grant_id":["2020YFC2009004","82272554"],"pubmed_authors":["Liu H","Zhang F","Li H","Tao L","Yang L","Hu Y","Cui L","Huang J","Liu N","Lv Y","Song C","Wang H","Jiang Y","Li Y","Yang Y","Wang T","Gao Y","Chen Y","Xue L","Wang X","Li B","Liu D","Yuan W"],"additional_accession":[]},"is_claimable":false,"name":"Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.","description":"We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly incr","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-07-15T10:59:26.916Z","creation":"2024-11-21T06:53:20.588Z"},"accession":"S-EPMC11371808","cross_references":{"pubmed":["39227626"],"doi":["10.1038/s41598-024-66267-8"]}}