biostudies-literatureWang HNational Key Research and Development ProgramNational Natural Science Foundation of China20519https://www.ebi.ac.uk/biostudies/studies/S-EPMC11371808biostudies-literatureUnknown14(1)We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly incrScientific reportsRandomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.PMC113718082020YFC200900482272554Liu HZhang FLi HTao LYang LHu YCui LHuang JLiu NLv YSong CWang HJiang YLi YYang YWang TGao YChen YXue LWang XLi BLiu DYuan WfalseRandomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly incr2024-01-01T00:00:00Z2024 Sep2026-07-15T10:59:26.916Z2024-11-21T06:53:20.588ZS-EPMC113718083922762610.1038/s41598-024-66267-8