{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Huang Y"],"funding":["Taishan Scholar Foundation of Shandong Province"],"pubmed_abstract":["Lymphocyte receptors independently evolved in both jawed and jawless vertebrates with similar adaptive immune responses. However, the diversity of functional subtypes and molecular architecture in jawless vertebrate lymphocytes, comparable to jawed species, is not well defined. Here, we profile the gills, intestines, and blood of the lamprey, Lampetra morii, with single-cell RNA sequencing, using a full-length transcriptome as a reference. Our findings reveal higher tissue-specific heterogeneity among T-like cells in contrast to B-like cells. Notably, we identify a unique T-like cell subtype expressing a homolog of the nonlymphoid hematopoietic growth factor receptor, MPL-like (MPL-L). These MPL-L+ T-like cells exhibit features distinct from T cells of jawed vertebrates, particularly in th"],"journal":["Nature communications"],"pagination":["7626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11372201"],"repository":["biostudies-literature"],"pubmed_title":["Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution."],"pmcid":["PMC11372201"],"pubmed_authors":["Liu K","Li C","Liu YY","Liu Q","Liu S","Pang Y","Wang HY","Shao C","Liu X","Li Y","Fan G","Huang Y","Li S","Wang Q","Zhang Y","Zhang X","Chen JY"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution.","description":"Lymphocyte receptors independently evolved in both jawed and jawless vertebrates with similar adaptive immune responses. However, the diversity of functional subtypes and molecular architecture in jawless vertebrate lymphocytes, comparable to jawed species, is not well defined. Here, we profile the gills, intestines, and blood of the lamprey, Lampetra morii, with single-cell RNA sequencing, using a full-length transcriptome as a reference. Our findings reveal higher tissue-specific heterogeneity among T-like cells in contrast to B-like cells. Notably, we identify a unique T-like cell subtype expressing a homolog of the nonlymphoid hematopoietic growth factor receptor, MPL-like (MPL-L). These MPL-L+ T-like cells exhibit features distinct from T cells of jawed vertebrates, particularly in th","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-01T17:40:15.635Z","creation":"2025-04-05T22:14:04.172Z"},"accession":"S-EPMC11372201","cross_references":{"pubmed":["39227584"],"doi":["10.1038/s41467-024-51763-2"]}}