biostudies-literatureWeykamp FDeutsche Forschungsgemeinschaft101573https://www.ebi.ac.uk/biostudies/studies/S-EPMC11372804biostudies-literatureUnknown9(9)<h4>Purpose</h4>Superior sulcus tumors are frequently treated with neoadjuvant chemoradiation therapy (nCRT) followed by surgery via a trimodal approach. The INKA study evaluated the replacement of photon irradiation by carbon ion radiation therapy (C12-RT) in this regimen.<h4>Methods and materials</h4>The prospective INKA study included patients with locally advanced non-small cell superior sulcus tumors (<cN3 cM0). Patients received 2 cycles of cisplatin and vinorelbine as per local standard. During the second cycle, 39 Gy(Relative biological effectiveness (RBE)) of hypofractionated C12-RT in 13 fractions were applied. Surgery following fludeoxyglucose F18 positron emission tomography-computed tomography restaging was performed 2 weeks later. The primary endpoint was feasibility and safeAdvances in radiation oncologyCarbon Ion Beam Radiation Therapy as Part of a Trimodal Therapy for Non-small Cell Superior Sulcus Tumors: The INKA Study.PMC11372804HE 2499/4-1KFO214Weykamp FSchaub LSchirmacher PThomas MDebus JWinter HHaberkorn UEllerbrock MAdeberg SEichhorn MHerfarth KfalseCarbon Ion Beam Radiation Therapy as Part of a Trimodal Therapy for Non-small Cell Superior Sulcus Tumors: The INKA Study.<h4>Purpose</h4>Superior sulcus tumors are frequently treated with neoadjuvant chemoradiation therapy (nCRT) followed by surgery via a trimodal approach. The INKA study evaluated the replacement of photon irradiation by carbon ion radiation therapy (C12-RT) in this regimen.<h4>Methods and materials</h4>The prospective INKA study included patients with locally advanced non-small cell superior sulcus tumors (<cN3 cM0). Patients received 2 cycles of cisplatin and vinorelbine as per local standard. During the second cycle, 39 Gy(Relative biological effectiveness (RBE)) of hypofractionated C12-RT in 13 fractions were applied. Surgery following fludeoxyglucose F18 positron emission tomography-computed tomography restaging was performed 2 weeks later. The primary endpoint was feasibility and safe2024-01-01T00:00:00Z2024 Sep2025-04-22T05:34:19.929Z2024-11-15T21:29:53.754ZS-EPMC113728043923423410.1016/j.adro.2024.101573