{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(35)"],"submitter":["Zhang S"],"pubmed_abstract":["The biosensing field faces a significant challenge in efficiently detecting multiple analytes in a single diagnostic sample in order to compete with other established multiplex molecular diagnostic technologies such as PCR and ELISA. In response, we have developed a colorimetric nanobiosensor based on multiple morphological forms of functionalized gold nanoparticles (AuNPs) for the simultaneous detection of the influenza virus and SARS-CoV-2 virus. Gold nanospheres (GNSp) were modified with oligonucleotides specific for the influenza A virus, while gold nanoshells (GNSh) were modified with oligonucleotides specific for the SARS-CoV-2 virus. In the presence of their respective targets, AuNPs remain stable due to DNA-DNA interactions; conversely, in the absence of targets, AuNPs aggregate. C"],"journal":["ACS omega"],"pagination":["37163-37169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11375896"],"repository":["biostudies-literature"],"pubmed_title":["Shape-Specific Gold Nanoparticles for Multiplex Biosensing Applications."],"pmcid":["PMC11375896"],"pubmed_authors":["Jiang J","Charconnet M","Peng Y","Zhang Y","Zhang L","Zhang S","Lawrie CH"],"additional_accession":[]},"is_claimable":false,"name":"Shape-Specific Gold Nanoparticles for Multiplex Biosensing Applications.","description":"The biosensing field faces a significant challenge in efficiently detecting multiple analytes in a single diagnostic sample in order to compete with other established multiplex molecular diagnostic technologies such as PCR and ELISA. In response, we have developed a colorimetric nanobiosensor based on multiple morphological forms of functionalized gold nanoparticles (AuNPs) for the simultaneous detection of the influenza virus and SARS-CoV-2 virus. Gold nanospheres (GNSp) were modified with oligonucleotides specific for the influenza A virus, while gold nanoshells (GNSh) were modified with oligonucleotides specific for the SARS-CoV-2 virus. In the presence of their respective targets, AuNPs remain stable due to DNA-DNA interactions; conversely, in the absence of targets, AuNPs aggregate. C","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-19T12:40:49.185Z","creation":"2025-04-19T12:40:49.185Z"},"accession":"S-EPMC11375896","cross_references":{"pubmed":["39246468"],"doi":["10.1021/acsomega.4c04385"]}}