biostudies-literatureFarling SNICHD NIH HHSDuke Medicine and EngineeringSchool of Medicine, Duke UniversityNational Institute of Child Health and Human Development638-646https://www.ebi.ac.uk/biostudies/studies/S-EPMC11375969biostudies-literatureUnknown52(3)We demonstrate a methodology which both improves oxygen transport and reduces or eliminates bubble formation in a novel hyperbaric membrane oxygenator catheter model system. Angular oscillations were introduced to a bundle of hollow fiber membranes (HFMs) supplied with hyperbaric 100% oxygen at average gauge pressures up to 0.35 barg. Oscillating bundles enabled delivery of an oxygen flux of up to 400 mL min^-1 m^-2 in an aqueous solution, a doubling over a previous non-oscillating setup. Similarly, the addition of angular oscillations facilitated a five-fold reduction in pressure to achieve similar oxygen flux. The increased angular speed of oscillation improved flux, while the addition of angular micro-oscillation variations resulted in flux reductions of 7-20% comparAnnals of biomedical engineeringOptimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation.PMC11375969T32 HD094671T32HD094671Klitzman BFarling SVesel TPDeshusses MACheifetz IMStraube TLfalseOptimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation.We demonstrate a methodology which both improves oxygen transport and reduces or eliminates bubble formation in a novel hyperbaric membrane oxygenator catheter model system. Angular oscillations were introduced to a bundle of hollow fiber membranes (HFMs) supplied with hyperbaric 100% oxygen at average gauge pressures up to 0.35 barg. Oscillating bundles enabled delivery of an oxygen flux of up to 400 mL min^-1 m^-2 in an aqueous solution, a doubling over a previous non-oscillating setup. Similarly, the addition of angular oscillations facilitated a five-fold reduction in pressure to achieve similar oxygen flux. The increased angular speed of oscillation improved flux, while the addition of angular micro-oscillation variations resulted in flux reductions of 7-20% compar2024-01-01T00:00:00Z2024 Mar2025-04-04T00:48:46.903Z2025-04-04T00:48:46.903ZS-EPMC113759693806231210.1007/s10439-023-03411-x