{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Florczyk SJ"],"funding":["NCRR NIH HHS","Intramural NIST DOC","U.S. Department of Commerce","National Science Foundation"],"pagination":["2302-2313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11376592"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(10)"],"pubmed_abstract":["Many biomaterial scaffolds have been advanced to provide synthetic cell niches for tissue engineering and drug screening applications; however, current methods for comparing scaffold niches focus on cell functional outcomes or attempt to normalize materials properties between different scaffold formats. We demonstrate a three-dimensional (3D) cellular morphotyping strategy for comparing biomaterial scaffold cell niches between different biomaterial scaffold formats. Primary human bone marrow stromal cells (hBMSCs) were cultured on 8 different biomaterial scaffolds, including fibrous scaffolds, hydrogels, and porous sponges, in 10 treatment groups to compare a variety of biomaterial scaffolds and cell morphologies. A bioinformatics approach was used to determine the 3D cellular morphotype f"],"journal":["ACS biomaterials science & engineering"],"pubmed_title":["A Bioinformatics 3D Cellular Morphotyping Strategy for Assessing Biomaterial Scaffold Niches."],"pmcid":["PMC11376592"],"funding_grant_id":["P40 RR017447","9999-NIST","PHY1205965"],"pubmed_authors":["Simon CG","Cardone A","Brady MC","Sarkar S","Bodhak S","Simon M","Baker PJ","Pine PS","Bajcsy P","Juba D","Florczyk SJ","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"A Bioinformatics 3D Cellular Morphotyping Strategy for Assessing Biomaterial Scaffold Niches.","description":"Many biomaterial scaffolds have been advanced to provide synthetic cell niches for tissue engineering and drug screening applications; however, current methods for comparing scaffold niches focus on cell functional outcomes or attempt to normalize materials properties between different scaffold formats. We demonstrate a three-dimensional (3D) cellular morphotyping strategy for comparing biomaterial scaffold cell niches between different biomaterial scaffold formats. Primary human bone marrow stromal cells (hBMSCs) were cultured on 8 different biomaterial scaffolds, including fibrous scaffolds, hydrogels, and porous sponges, in 10 treatment groups to compare a variety of biomaterial scaffolds and cell morphologies. A bioinformatics approach was used to determine the 3D cellular morphotype f","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-05-08T20:05:54.171Z","creation":"2025-04-05T14:38:52.756Z"},"accession":"S-EPMC11376592","cross_references":{"pubmed":["33445289"],"doi":["10.1021/acsbiomaterials.7b00473"]}}