{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parikh R"],"funding":["Melanoma Research Alliance (MRA)","European Research Council","Israel Science Foundation","Melanoma Research Alliance","Israel Science Foundation (ISF)","CHE | Israeli Centers for Research Excellence","CHE | Israeli Centers for Research Excellence (I-CORE)"],"pagination":["3553-3586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11377571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(17)"],"pubmed_abstract":["Extracellular vesicles (EVs) are important mediators of communication between cells. Here, we reveal a new mode of intercellular communication by melanosomes, large EVs secreted by melanocytes for melanin transport. Unlike small EVs, which are disintegrated within the receiver cell, melanosomes stay intact within them, gain a unique protein signature, and can then be further transferred to another cell as \"second-hand\" EVs. We show that melanoma-secreted melanosomes passaged through epidermal keratinocytes or dermal fibroblasts can be further engulfed by resident macrophages. This process leads to macrophage polarization into pro-tumor or pro-immune cell infiltration phenotypes. Melanosomes that are transferred through fibroblasts can carry AKT1, which induces VEGF secretion from macrophag"],"journal":["The EMBO journal"],"pubmed_title":["Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification."],"pmcid":["PMC11377571"],"funding_grant_id":["41/11","129/13","402792","726225"],"pubmed_authors":["Vaknine H","Ashery-Padan R","Ovadia S","Greenberger S","Parikh S","Nizri E","Elgavish S","Berzin D","Carmi Y","Levy C","Nevo Y","Parikh R","Luxenburg C","Maliah A","Scope A","Zaremba L","Sagi I","Plaschkes I","Levesque MP","Khaled M","Likonen D","Mohan V","Kobiler O","Hoheisel JD"],"additional_accession":[]},"is_claimable":false,"name":"Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification.","description":"Extracellular vesicles (EVs) are important mediators of communication between cells. Here, we reveal a new mode of intercellular communication by melanosomes, large EVs secreted by melanocytes for melanin transport. Unlike small EVs, which are disintegrated within the receiver cell, melanosomes stay intact within them, gain a unique protein signature, and can then be further transferred to another cell as \"second-hand\" EVs. We show that melanoma-secreted melanosomes passaged through epidermal keratinocytes or dermal fibroblasts can be further engulfed by resident macrophages. This process leads to macrophage polarization into pro-tumor or pro-immune cell infiltration phenotypes. Melanosomes that are transferred through fibroblasts can carry AKT1, which induces VEGF secretion from macrophag","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-03T03:38:11.843Z","creation":"2025-04-06T19:28:50.396Z"},"accession":"S-EPMC11377571","cross_references":{"pubmed":["38719996"],"doi":["10.1038/s44318-024-00103-7"]}}