{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu M"],"funding":["Medical Science and Technology Project of Zhejiang Province","Zhejiang Traditional Chinese Medicine Administration"],"pagination":["260-269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11377941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(4)"],"pubmed_abstract":["<h4>Purpose</h4>Controversies persist regarding contraindications for nipple-sparing mastectomy (NSM). This study aimed to assess the accuracy of subareolar frozen section analysis and identify risk factors for nipple-areola complex (NAC) recurrence post NSM.<h4>Methods</h4>Consecutive cases of primary invasive breast cancer undergoing NSM at our single center from January 2015 to December 2020 were retrospectively reviewed.<h4>Results</h4>The nipples were retained in 126 patients (127 breasts), and the areola was retained with nipple excision for five breasts. Frozen section analysis demonstrated a sensitivity of 81.8% and specificity of 95.3%. The NAC recurrence rate was 4.3% over a median follow-up period of 48 (30-105) months. An atypical ductal hyperplasia (ADH) at the margin emerged "],"journal":["Journal of breast cancer"],"pubmed_title":["Safety of Atypical Ductal Hyperplasia at the Nipple Margin in Nipple-Sparing Mastectomy."],"pmcid":["PMC11377941"],"funding_grant_id":["2020ZB035","2021RC045"],"pubmed_authors":["Zhu M","Fang J","Mao J","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"Safety of Atypical Ductal Hyperplasia at the Nipple Margin in Nipple-Sparing Mastectomy.","description":"<h4>Purpose</h4>Controversies persist regarding contraindications for nipple-sparing mastectomy (NSM). This study aimed to assess the accuracy of subareolar frozen section analysis and identify risk factors for nipple-areola complex (NAC) recurrence post NSM.<h4>Methods</h4>Consecutive cases of primary invasive breast cancer undergoing NSM at our single center from January 2015 to December 2020 were retrospectively reviewed.<h4>Results</h4>The nipples were retained in 126 patients (127 breasts), and the areola was retained with nipple excision for five breasts. Frozen section analysis demonstrated a sensitivity of 81.8% and specificity of 95.3%. The NAC recurrence rate was 4.3% over a median follow-up period of 48 (30-105) months. An atypical ductal hyperplasia (ADH) at the margin emerged ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-04-08T08:20:32.394Z","creation":"2025-02-19T02:34:34.891Z"},"accession":"S-EPMC11377941","cross_references":{"pubmed":["39069781"],"doi":["10.4048/jbc.2024.0077"]}}