biostudies-literatureZhu MMedical Science and Technology Project of Zhejiang ProvinceZhejiang Traditional Chinese Medicine Administration260-269https://www.ebi.ac.uk/biostudies/studies/S-EPMC11377941biostudies-literatureUnknown27(4)<h4>Purpose</h4>Controversies persist regarding contraindications for nipple-sparing mastectomy (NSM). This study aimed to assess the accuracy of subareolar frozen section analysis and identify risk factors for nipple-areola complex (NAC) recurrence post NSM.<h4>Methods</h4>Consecutive cases of primary invasive breast cancer undergoing NSM at our single center from January 2015 to December 2020 were retrospectively reviewed.<h4>Results</h4>The nipples were retained in 126 patients (127 breasts), and the areola was retained with nipple excision for five breasts. Frozen section analysis demonstrated a sensitivity of 81.8% and specificity of 95.3%. The NAC recurrence rate was 4.3% over a median follow-up period of 48 (30-105) months. An atypical ductal hyperplasia (ADH) at the margin emerged Journal of breast cancerSafety of Atypical Ductal Hyperplasia at the Nipple Margin in Nipple-Sparing Mastectomy.PMC113779412020ZB0352021RC045Zhu MFang JMao JChen DfalseSafety of Atypical Ductal Hyperplasia at the Nipple Margin in Nipple-Sparing Mastectomy.<h4>Purpose</h4>Controversies persist regarding contraindications for nipple-sparing mastectomy (NSM). This study aimed to assess the accuracy of subareolar frozen section analysis and identify risk factors for nipple-areola complex (NAC) recurrence post NSM.<h4>Methods</h4>Consecutive cases of primary invasive breast cancer undergoing NSM at our single center from January 2015 to December 2020 were retrospectively reviewed.<h4>Results</h4>The nipples were retained in 126 patients (127 breasts), and the areola was retained with nipple excision for five breasts. Frozen section analysis demonstrated a sensitivity of 81.8% and specificity of 95.3%. The NAC recurrence rate was 4.3% over a median follow-up period of 48 (30-105) months. An atypical ductal hyperplasia (ADH) at the margin emerged 2024-01-01T00:00:00Z2024 Aug2026-04-08T08:20:32.394Z2025-02-19T02:34:34.891ZS-EPMC113779413906978110.4048/jbc.2024.0077