biostudies-literatureUnknown20(11)Hu YMacrophages are the most abundant alternative immune cells in the tumor microenvironment (TME). The cross-talk between macrophages and tumor cells provides an important shelter for the occurrence and development of tumors. As an important information transfer medium, exosomes play an important role in intercellular communication. Nonetheless, how exosomal lncRNAs coordinate the communication between tumor cells and immune cells in hepatocellular carcinoma (HCC) is incompletely understood. We found that HCC exosomes-derived antisense RNA of SLC16A1(SLC16A1-AS1) promoted the malignant progression of HCC by regulating macrophage M2-type polarization. Mechanistically, the HCC exosomal SLC16A1-AS1 enhanced mRNA stabilization of SLC16A1 in macrophage by promoting the interaction between 3' untraInternational journal of biological sciences4341-4363https://www.ebi.ac.uk/biostudies/studies/S-EPMC11379075biostudies-literatureExosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.PMC11379075Hu YZeng ZWang FWang HHan SZhao YLi YHuang YLv GZhang YZhao GZhuo WXiong HHu PfalseExosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.Macrophages are the most abundant alternative immune cells in the tumor microenvironment (TME). The cross-talk between macrophages and tumor cells provides an important shelter for the occurrence and development of tumors. As an important information transfer medium, exosomes play an important role in intercellular communication. Nonetheless, how exosomal lncRNAs coordinate the communication between tumor cells and immune cells in hepatocellular carcinoma (HCC) is incompletely understood. We found that HCC exosomes-derived antisense RNA of SLC16A1(SLC16A1-AS1) promoted the malignant progression of HCC by regulating macrophage M2-type polarization. Mechanistically, the HCC exosomal SLC16A1-AS1 enhanced mRNA stabilization of SLC16A1 in macrophage by promoting the interaction between 3' untra2024-01-01T00:00:00Z20242025-04-22T10:55:10.016Z2025-04-05T23:45:50.11ZS-EPMC113790753924782210.7150/ijbs.94440