biostudies-literatureChow KWNCATS NIH HHS2389-2397https://www.ebi.ac.uk/biostudies/studies/S-EPMC11380462biostudies-literatureUnknown68(6)<h4>Background</h4>Hepatic encephalopathy (HE) is a major cause of mortality and morbidity in patients with cirrhosis. Lactulose non-adherence is one of the most frequently reported precipitants of hospital admission for HE.<h4>Aims</h4>We aimed to identify which factors contribute most to lactulose non-adherence and propose strategies to promote greater adherence and utilization of lactulose.<h4>Methods</h4>Participants in this study consisted of patients with cirrhosis who were taking lactulose for prevention of HE. Subjects were administered the Morisky Adherence Scale 8 (MAS-8) and a customized 16-question survey that assessed barriers to lactulose adherence. Results from the MAS-8 were used to stratify subjects into "adherent" and "non-adherent" groups. Survey responses were compared Digestive diseases and sciencesBarriers to Lactulose Adherence in Patients with Cirrhosis and Hepatic Encephalopathy.PMC11380462UL1 TR001881Ibrahim BMChen KTDang LChow KWDang ASaab SJackson NJYum JJfalseBarriers to Lactulose Adherence in Patients with Cirrhosis and Hepatic Encephalopathy.<h4>Background</h4>Hepatic encephalopathy (HE) is a major cause of mortality and morbidity in patients with cirrhosis. Lactulose non-adherence is one of the most frequently reported precipitants of hospital admission for HE.<h4>Aims</h4>We aimed to identify which factors contribute most to lactulose non-adherence and propose strategies to promote greater adherence and utilization of lactulose.<h4>Methods</h4>Participants in this study consisted of patients with cirrhosis who were taking lactulose for prevention of HE. Subjects were administered the Morisky Adherence Scale 8 (MAS-8) and a customized 16-question survey that assessed barriers to lactulose adherence. Results from the MAS-8 were used to stratify subjects into "adherent" and "non-adherent" groups. Survey responses were compared 2023-01-01T00:00:00Z2023 Jun2025-04-05T14:38:36.871Z2025-04-05T14:38:36.871ZS-EPMC113804623711937610.1007/s10620-023-07935-z