biostudies-literatureLiu LXi'an People's Hospital (Xi'an Fourth Hospital) Scientific Research Incubation FundXi&apos;an People&apos;s Hospital (Xi&apos;an Fourth Hospital) Scientific Research Incubation Fund214https://www.ebi.ac.uk/biostudies/studies/S-EPMC11384644biostudies-literatureUnknown24(1)<h4>Objective</h4>This study assessed the diagnostic value of microRNA-200 (miR-200) expression in peripheral blood-derived extracellular vesicles (EVs) in early-stage non-small cell lung cancer (NSCLC).<h4>Methods</h4>This study retrospectively analyzed 100 healthy volunteers (the control group) receiving physical examinations, 168 early-stage NSCLC patients (the NSCLC group), and 128 patients with benign lung nodules (the benign group). The basic and clinical data of participants were obtained, including age, sex, smoking history, carbohydrate antigen 242 (CA242), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), forced expiratory volume in 1 s, maximal voluntary ventilation, forced vital capacity, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and miR-200 expressClinical and experimental medicineDiagnostic value of microRNA-200 expression in peripheral blood-derived extracellular vesicles in early-stage non-small cell lung cancer.PMC11384644No. FZ-69 and No. LH-11Liu HZhang FNiu DLiu LGuo XLei TfalseDiagnostic value of microRNA-200 expression in peripheral blood-derived extracellular vesicles in early-stage non-small cell lung cancer.<h4>Objective</h4>This study assessed the diagnostic value of microRNA-200 (miR-200) expression in peripheral blood-derived extracellular vesicles (EVs) in early-stage non-small cell lung cancer (NSCLC).<h4>Methods</h4>This study retrospectively analyzed 100 healthy volunteers (the control group) receiving physical examinations, 168 early-stage NSCLC patients (the NSCLC group), and 128 patients with benign lung nodules (the benign group). The basic and clinical data of participants were obtained, including age, sex, smoking history, carbohydrate antigen 242 (CA242), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), forced expiratory volume in 1 s, maximal voluntary ventilation, forced vital capacity, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and miR-200 express2024-01-01T00:00:00Z2024 Sep2025-04-26T21:06:04.996Z2025-04-06T16:40:56.191ZS-EPMC113846443924915710.1007/s10238-024-01455-4