{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Allaw AB"],"funding":["NHLBI NIH HHS"],"pagination":["529-537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11385397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(8)"],"pubmed_abstract":["<h4>Background</h4>The benefit of pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) is well established; its efficacy in patients with heart failure preserved ejection fraction (HFpEF) is less clear.<h4>Objective</h4>The objective of the study was to compare AF and heart failure (HF) rehospitalizations after PVI in patients with HFpEF vs HFrEF.<h4>Methods</h4>The IBM MarketScan Database was used to identify patients undergoing PVI for AF. Patients were categorized by HF status: absence of HF, presence of HFrEF, or presence of HFpEF. Primary outcomes were HF and arrhythmia hospitalizations after PVI.<h4>Results</h4>A total of 32,524 patients were analyzed: 27,900 with no HF (86%), 2948 with HFrEF (9%), and 1676 with HFpEF (5%). Compared with those with no HF, both patients with HFrEF and HFpEF were more likely to be hospitalized for HF (hazard ratio [HR] 7.27; <i>P</i> < .01 for HFrEF and HR 9.46; <i>P</i> < .01 for HFpEF) and for AF (HR 1.17; <i>P</i> < .01 for HFrEF and HR 1.74; <i>P</i> < .01 for HFpEF) after PVI. In matched analysis, 23% of patients with HFrEF and 24% patients with HFpEF demonstrated a reduction in HF hospitalizations (<i>P</i> = .31) and approximately one-third demonstrated decreased arrhythmia rehospitalizations (<i>P</i> = .57) in the 6 months after PVI. Compared with those with HFrEF in longer-term follow-up (>1 year), patients with HFpEF were more likely to have HF (HR 1.30; <i>P</i> < .01) and arrhythmia (HR 1.19; <i>P</i> < .01) rehospitalizations.<h4>Conclusion</h4>Reductions in HF and arrhythmia hospitalizations are observed early after PVI across all patients with HF, but patients with HFpEF demonstrate higher HF rehospitalization and arrhythmia recurrence in longer-term follow-up than do patients with HFrEF."],"journal":["Heart rhythm O2"],"pubmed_title":["Comparing outcomes after pulmonary vein isolation in patients with systolic and diastolic heart failure."],"pmcid":["PMC11385397"],"funding_grant_id":["T32 HL007381"],"pubmed_authors":["Gampa A","Rao S","Guo J","Ozcan C","Besser SA","Yeshwant S","Upadhyay GA","Roy D","Aziz Z","Beaser AD","Treger J","Allaw AB"],"additional_accession":[]},"is_claimable":false,"name":"Comparing outcomes after pulmonary vein isolation in patients with systolic and diastolic heart failure.","description":"<h4>Background</h4>The benefit of pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) is well established; its efficacy in patients with heart failure preserved ejection fraction (HFpEF) is less clear.<h4>Objective</h4>The objective of the study was to compare AF and heart failure (HF) rehospitalizations after PVI in patients with HFpEF vs HFrEF.<h4>Methods</h4>The IBM MarketScan Database was used to identify patients undergoing PVI for AF. Patients were categorized by HF status: absence of HF, presence of HFrEF, or presence of HFpEF. Primary outcomes were HF and arrhythmia hospitalizations after PVI.<h4>Results</h4>A total of 32,524 patients were analyzed: 27,900 with no HF (86%), 2948 with HFrEF (9%), and 1676 with HFpEF (5%). Compared with those with no HF, both patients with HFrEF and HFpEF were more likely to be hospitalized for HF (hazard ratio [HR] 7.27; <i>P</i> < .01 for HFrEF and HR 9.46; <i>P</i> < .01 for HFpEF) and for AF (HR 1.17; <i>P</i> < .01 for HFrEF and HR 1.74; <i>P</i> < .01 for HFpEF) after PVI. In matched analysis, 23% of patients with HFrEF and 24% patients with HFpEF demonstrated a reduction in HF hospitalizations (<i>P</i> = .31) and approximately one-third demonstrated decreased arrhythmia rehospitalizations (<i>P</i> = .57) in the 6 months after PVI. Compared with those with HFrEF in longer-term follow-up (>1 year), patients with HFpEF were more likely to have HF (HR 1.30; <i>P</i> < .01) and arrhythmia (HR 1.19; <i>P</i> < .01) rehospitalizations.<h4>Conclusion</h4>Reductions in HF and arrhythmia hospitalizations are observed early after PVI across all patients with HF, but patients with HFpEF demonstrate higher HF rehospitalization and arrhythmia recurrence in longer-term follow-up than do patients with HFrEF.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T09:49:05.995Z","creation":"2025-04-04T09:49:05.995Z"},"accession":"S-EPMC11385397","cross_references":{"pubmed":["39263616"],"doi":["10.1016/j.hroo.2024.07.003"]}}