{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brewer TE"],"funding":["Swiss National Science Foundation","European Research Council"],"pagination":["msae180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11388002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(9)"],"pubmed_abstract":["Prolines cause ribosomes to stall during translation due to their rigid structure. This phenomenon occurs in all domains of life and is exacerbated at polyproline motifs. Such stalling can be eased by the elongation factor P (EF-P) in bacteria. We discovered a potential connection between the loss of ancestral EF-P, the appearance of horizontally transferred EF-P variants, and genomic signs of EF-P dysfunction. Horizontal transfer of the efp gene has occurred several times among bacteria and is associated with the loss of highly conserved polyproline motifs. In this study, we pinpoint cases of horizontal EF-P transfer among a diverse set of bacteria and examine genomic features associated with these events in the phyla Thermotogota and Planctomycetes. In these phyla, horizontal EF-P transf"],"journal":["Molecular biology and evolution"],"pubmed_title":["Horizontal Gene Transfer of a key Translation Factor and its Role in Polyproline Proteome Evolution."],"pmcid":["PMC11388002"],"funding_grant_id":["172887","739874"],"pubmed_authors":["Brewer TE","Wagner A"],"additional_accession":[]},"is_claimable":false,"name":"Horizontal Gene Transfer of a key Translation Factor and its Role in Polyproline Proteome Evolution.","description":"Prolines cause ribosomes to stall during translation due to their rigid structure. This phenomenon occurs in all domains of life and is exacerbated at polyproline motifs. Such stalling can be eased by the elongation factor P (EF-P) in bacteria. We discovered a potential connection between the loss of ancestral EF-P, the appearance of horizontally transferred EF-P variants, and genomic signs of EF-P dysfunction. Horizontal transfer of the efp gene has occurred several times among bacteria and is associated with the loss of highly conserved polyproline motifs. In this study, we pinpoint cases of horizontal EF-P transfer among a diverse set of bacteria and examine genomic features associated with these events in the phyla Thermotogota and Planctomycetes. In these phyla, horizontal EF-P transf","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-09T07:16:05.651Z","creation":"2025-04-06T16:10:40.906Z"},"accession":"S-EPMC11388002","cross_references":{"pubmed":["39189989"],"doi":["10.1093/molbev/msae180"]}}