{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Kim C"],"pubmed_abstract":["<h4>Introduction</h4>Bruton's tyrosine kinase (BTK) and interleukin (IL)-2 Inducible T-cell Kinase (ITK) inhibitors have anti-inflammatory properties. We investigated the therapeutic effect of ibrutinib, an orally bioavailable BTK/ITK inhibitor, in a mouse model of Graves' orbitopathy (GO).<h4>Methods</h4>Genetic immunization was performed through intramuscular administration of the recombinant plasmid, pCMV6-hTSHR cDNA, to 8-week-old female BALB/c mice. Serum levels of T3, T4, and thyroid-stimulating hormone receptor (TSHR) antibodies (TRAbs) were quantified using enzyme-linked immunosorbent assay. Histopathological changes in orbital tissues were examined using immunohistochemistry (IHC) staining for TSHR and various inflammatory markers. Following successful genetic immunization, ibruti"],"journal":["Frontiers in endocrinology"],"pagination":["1420024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11392736"],"repository":["biostudies-literature"],"pubmed_title":["Impact of ibrutinib on inflammation in a mouse model of Graves' orbitopathy."],"pmcid":["PMC11392736"],"pubmed_authors":["Kim C","Yang JW","Chung JK","Park JH","Jang SY","Choi YJ","Yoon JS","Jun HO","Park TK"],"additional_accession":[]},"is_claimable":false,"name":"Impact of ibrutinib on inflammation in a mouse model of Graves' orbitopathy.","description":"<h4>Introduction</h4>Bruton's tyrosine kinase (BTK) and interleukin (IL)-2 Inducible T-cell Kinase (ITK) inhibitors have anti-inflammatory properties. We investigated the therapeutic effect of ibrutinib, an orally bioavailable BTK/ITK inhibitor, in a mouse model of Graves' orbitopathy (GO).<h4>Methods</h4>Genetic immunization was performed through intramuscular administration of the recombinant plasmid, pCMV6-hTSHR cDNA, to 8-week-old female BALB/c mice. Serum levels of T3, T4, and thyroid-stimulating hormone receptor (TSHR) antibodies (TRAbs) were quantified using enzyme-linked immunosorbent assay. Histopathological changes in orbital tissues were examined using immunohistochemistry (IHC) staining for TSHR and various inflammatory markers. Following successful genetic immunization, ibruti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-04T03:08:02.581Z","creation":"2025-04-04T09:48:48.51Z"},"accession":"S-EPMC11392736","cross_references":{"pubmed":["39280007"],"doi":["10.3389/fendo.2024.1420024"]}}