biostudies-literatureYousef MNCI NIH HHS1519-1529https://www.ebi.ac.uk/biostudies/studies/S-EPMC11393757biostudies-literatureUnknown10(11)<h4>Importance</h4>Disparity in overall survival (OS) and differences in the frequency of driver gene variants by race and ethnicity have been separately observed in patients with colorectal cancer; however, how these differences contribute to survival disparity is unknown.<h4>Objective</h4>To quantify the association of molecular, socioeconomic, and clinical covariates with racial and ethnic disparities in overall survival among patients with colorectal cancer.<h4>Design, setting, and participants</h4>This single-center cohort study was conducted at a tertiary-level cancer center using relevant data on all patients diagnosed with colorectal cancer from January 1, 1973, to March 1, 2023. The relative contribution of variables to the disparity was determined using mediation analysis with seJAMA oncologyMolecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival.PMC11393757R01 CA268380Kopetz SAlfaro KParseghian CLee MChowdhury SUppal AOverman MJYousef AHigbie VGoldstein DDasari ASun RShen JPJohnson BWang WKee BWhite MGKnafl MFanaeian MMZeineddine MMorelli MPRaghav KPYousef MWillis JBent AZeineddine FMorris VKVilar EHuey RWolff RHornstein NPeterson JHalperin DfalseMolecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival.<h4>Importance</h4>Disparity in overall survival (OS) and differences in the frequency of driver gene variants by race and ethnicity have been separately observed in patients with colorectal cancer; however, how these differences contribute to survival disparity is unknown.<h4>Objective</h4>To quantify the association of molecular, socioeconomic, and clinical covariates with racial and ethnic disparities in overall survival among patients with colorectal cancer.<h4>Design, setting, and participants</h4>This single-center cohort study was conducted at a tertiary-level cancer center using relevant data on all patients diagnosed with colorectal cancer from January 1, 1973, to March 1, 2023. The relative contribution of variables to the disparity was determined using mediation analysis with se2024-01-01T00:00:00Z2024 Nov2026-06-03T02:20:32.4Z2026-04-23T03:10:11.473ZS-EPMC113937573926460710.1001/jamaoncol.2024.3666