biostudies-literatureUnknown14(17)Nguyen Tat TIn forensics, one-third of sudden deaths remain unexplained after a forensic autopsy. A majority of these sudden unexplained deaths (SUDs) are considered to be caused by inherited cardiovascular diseases. In this study, we investigated 40 young SUD cases (<40 years), with non-diagnostic structural cardiac abnormalities, using Targeted NGS (next-generation sequencing) for 167 genes previously associated with inherited cardiomyopathies and channelopathies. Fifteen cases identified 17 variants on related genes including the following: <i>AKAP9</i>, <i>CSRP3</i>, <i>GSN</i>, <i>HTRA1</i>, <i>KCNA5</i>, <i>LAMA4</i>, <i>MYBPC3</i>, <i>MYH6</i>, <i>MYLK</i>, <i>RYR2</i>, <i>SCN5A</i>, <i>SCN10A</i>, <i>SLC4A3</i>, <i>TNNI3</i>, <i>TNNI3K</i>, and <i>TNNT2</i>. Of these, eight variants were novelDiagnostics (Basel, Switzerland)1876https://www.ebi.ac.uk/biostudies/studies/S-EPMC11394071biostudies-literatureIdentifying the Pathogenic Variants in Heart Genes in Vietnamese Sudden Unexplained Death Victims by Next-Generation Sequencing.PMC11394071Luu Sy HTung NVDang Viet DLien NTKTa Van TXuan NTNguyen Tat THoang NHNguyen Thi HThanh LTfalseIdentifying the Pathogenic Variants in Heart Genes in Vietnamese Sudden Unexplained Death Victims by Next-Generation Sequencing.In forensics, one-third of sudden deaths remain unexplained after a forensic autopsy. A majority of these sudden unexplained deaths (SUDs) are considered to be caused by inherited cardiovascular diseases. In this study, we investigated 40 young SUD cases (<40 years), with non-diagnostic structural cardiac abnormalities, using Targeted NGS (next-generation sequencing) for 167 genes previously associated with inherited cardiomyopathies and channelopathies. Fifteen cases identified 17 variants on related genes including the following: <i>AKAP9</i>, <i>CSRP3</i>, <i>GSN</i>, <i>HTRA1</i>, <i>KCNA5</i>, <i>LAMA4</i>, <i>MYBPC3</i>, <i>MYH6</i>, <i>MYLK</i>, <i>RYR2</i>, <i>SCN5A</i>, <i>SCN10A</i>, <i>SLC4A3</i>, <i>TNNI3</i>, <i>TNNI3K</i>, and <i>TNNT2</i>. Of these, eight variants were novel2024-01-01T00:00:00Z2024 Aug2026-04-08T18:38:27.683Z2025-04-04T01:38:25.939ZS-EPMC113940713927266110.3390/diagnostics14171876