{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de la Cruz-Thea B"],"funding":["Secretary of Science and Technology of the National University of Córdoba (SECyT), Argentina","Argentina and the National Scientific and Technical Research Council of Argentina","Deutsche Forschungsgemeinschaft","National Scientific and Technical Research Council of Argentina","Argentinian National Agency of Scientific Promotion","Bayerische Forschungsstiftung","Bayerische Forschungsstiftung (FORTiTher)","Secretary of Science and Technology of the National University of Córdoba"],"pagination":["9497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11394763"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(17)"],"pubmed_abstract":["Vascular smooth muscle cells (SMCs) can transition between a quiescent contractile or \"differentiated\" phenotype and a \"proliferative-dedifferentiated\" phenotype in response to environmental cues, similar to what in occurs in the wound healing process observed in fibroblasts. When dysregulated, these processes contribute to the development of various lung and cardiovascular diseases such as Chronic Obstructive Pulmonary Disease (COPD). Long non-coding RNAs (lncRNAs) have emerged as key modulators of SMC differentiation and phenotypic changes. In this study, we examined the expression of lncRNAs in primary human pulmonary artery SMCs (hPASMCs) during cell-to-cell contact-induced SMC differentiation. We discovered a novel lncRNA, which we named Differentiation And Growth Arrest-Related lncRN"],"journal":["International journal of molecular sciences"],"pubmed_title":["Differentiation and Growth-Arrest-Related lncRNA (<i>DAGAR</i>): Initial Characterization in Human Smooth Muscle and Fibroblast Cells."],"pmcid":["PMC11394763"],"funding_grant_id":["PICT-2016-0189","PIP-2015","Consolidar 2018-2021","FOR2127","FORTiTher","PICT-2016-0189 and PICT-PRH-00007","DFG, FOR2127","PICT-PRH-00007","Consolidar-2018"],"pubmed_authors":["de la Cruz-Thea B","Strieder N","Peinado VI","Bruckmann A","Musri MM","Natali L","Ho-Xuan H","Coll-Bonfill N","Meister G"],"additional_accession":[]},"is_claimable":false,"name":"Differentiation and Growth-Arrest-Related lncRNA (<i>DAGAR</i>): Initial Characterization in Human Smooth Muscle and Fibroblast Cells.","description":"Vascular smooth muscle cells (SMCs) can transition between a quiescent contractile or \"differentiated\" phenotype and a \"proliferative-dedifferentiated\" phenotype in response to environmental cues, similar to what in occurs in the wound healing process observed in fibroblasts. When dysregulated, these processes contribute to the development of various lung and cardiovascular diseases such as Chronic Obstructive Pulmonary Disease (COPD). Long non-coding RNAs (lncRNAs) have emerged as key modulators of SMC differentiation and phenotypic changes. In this study, we examined the expression of lncRNAs in primary human pulmonary artery SMCs (hPASMCs) during cell-to-cell contact-induced SMC differentiation. We discovered a novel lncRNA, which we named Differentiation And Growth Arrest-Related lncRN","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-30T03:18:17.868Z","creation":"2025-04-26T19:37:57.291Z"},"accession":"S-EPMC11394763","cross_references":{"pubmed":["39273443"],"doi":["10.3390/ijms25179497"]}}