{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Walker IS"],"pubmed_abstract":["<h4>Background</h4>Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies, but the features of the antibody response are poorly defined.<h4>Methods</h4>In Malawian children with cerebral or uncomplicated malaria, we characterized the antibody response to 39 recombinant PfEMP1 Duffy binding like (DBL) domains or cysteine-rich interdomain regions (CIDRs) in detail, including measures of antibody classes, subclasses, and engagement with Fcγ receptors and complement. Using elastic net regularized logistic regression, we identified a combination of seven antibody targets and Fc features that best distinguished between child"],"journal":["BMC medicine"],"pagination":["388"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11396342"],"repository":["biostudies-literature"],"pubmed_title":["A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children."],"pmcid":["PMC11396342"],"pubmed_authors":["Takashima E","Alemu A","Mandala W","Damelang T","Seydel KB","Hasang W","Harawa V","Rambhatla JS","Opi DH","Tsuboi T","Chung AW","Dini S","Jensen ATR","Rogerson SJ","Simpson JA","Walker IS","Taylor TE","Aitken EH","Duffy MF"],"additional_accession":[]},"is_claimable":false,"name":"A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children.","description":"<h4>Background</h4>Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies, but the features of the antibody response are poorly defined.<h4>Methods</h4>In Malawian children with cerebral or uncomplicated malaria, we characterized the antibody response to 39 recombinant PfEMP1 Duffy binding like (DBL) domains or cysteine-rich interdomain regions (CIDRs) in detail, including measures of antibody classes, subclasses, and engagement with Fcγ receptors and complement. Using elastic net regularized logistic regression, we identified a combination of seven antibody targets and Fc features that best distinguished between child","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-02T22:20:42.726Z","creation":"2025-04-04T18:53:21.417Z"},"accession":"S-EPMC11396342","cross_references":{"pubmed":["39267089"],"doi":["10.1186/s12916-024-03604-8"]}}