biostudies-literatureUnknown22(1)Walker IS<h4>Background</h4>Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies, but the features of the antibody response are poorly defined.<h4>Methods</h4>In Malawian children with cerebral or uncomplicated malaria, we characterized the antibody response to 39 recombinant PfEMP1 Duffy binding like (DBL) domains or cysteine-rich interdomain regions (CIDRs) in detail, including measures of antibody classes, subclasses, and engagement with Fcγ receptors and complement. Using elastic net regularized logistic regression, we identified a combination of seven antibody targets and Fc features that best distinguished between childBMC medicine388https://www.ebi.ac.uk/biostudies/studies/S-EPMC11396342biostudies-literatureA systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children.PMC11396342Takashima EAlemu AMandala WDamelang TSeydel KBHasang WHarawa VRambhatla JSOpi DHTsuboi TChung AWDini SJensen ATRRogerson SJSimpson JAWalker ISTaylor TEAitken EHDuffy MFfalseA systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children.<h4>Background</h4>Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies, but the features of the antibody response are poorly defined.<h4>Methods</h4>In Malawian children with cerebral or uncomplicated malaria, we characterized the antibody response to 39 recombinant PfEMP1 Duffy binding like (DBL) domains or cysteine-rich interdomain regions (CIDRs) in detail, including measures of antibody classes, subclasses, and engagement with Fcγ receptors and complement. Using elastic net regularized logistic regression, we identified a combination of seven antibody targets and Fc features that best distinguished between child2024-01-01T00:00:00Z2024 Sep2026-06-02T22:20:42.726Z2025-04-04T18:53:21.417ZS-EPMC113963423926708910.1186/s12916-024-03604-8