{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao ZZ"],"funding":["Postdoctoral Research Funding of Henan Province","Scientific and Technological Key Project in Henan Province","National Natural Science Foundation of China","the Scientific and Technological Key Project in Henan Province","Joint Fund of Provincial Science and Technology Plan of Henan Province","Program for Innovative Research Team (in Science and Technology) in University of Henan Province"],"pagination":["4104"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11397010"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(17)"],"pubmed_abstract":["Psoriasis, an immune-mediated inflammatory skin disorder, seriously affects the quality of life of nearly four percent of the world population. <i>Euphorbia helioscopia</i> L. is the monarch constituent of Chinese ZeQi powder preparation for psoriasis, so it is necessary to illustrate its active ingredients. Thus, twenty-three diterpenoids, including seven new ones, were isolated from the whole herb of <i>E. helioscopia</i> L. Compounds <b>1</b> and <b>2</b>, each featuring a 2,3-dicarboxylic functionality, are the first examples in the <i>ent</i>-2,3-<i>sceo</i>-atisane or the <i>ent</i>-2,3-<i>sceo</i>-abietane family. Extensive spectroscopic analysis (1D, 2D NMR, and HRMS data) and computational methods were used to confirm their structures and absolute configurations. According to the "],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Diterpenoids with Potent Anti-Psoriasis Activity from <i>Euphorbia helioscopia</i> L."],"pmcid":["PMC11397010"],"funding_grant_id":["232102310426 and 242102310312","232301420094","82003607","24IRTSTHN039","232102310426","242102310312","HN2022078"],"pubmed_authors":["He HJ","Sun YJ","Zhao ZZ","Liang XB","Xue GM","Chen H","Zheng XK","Zhao YS","Bian LN","Feng WS"],"additional_accession":[]},"is_claimable":false,"name":"Diterpenoids with Potent Anti-Psoriasis Activity from <i>Euphorbia helioscopia</i> L.","description":"Psoriasis, an immune-mediated inflammatory skin disorder, seriously affects the quality of life of nearly four percent of the world population. <i>Euphorbia helioscopia</i> L. is the monarch constituent of Chinese ZeQi powder preparation for psoriasis, so it is necessary to illustrate its active ingredients. Thus, twenty-three diterpenoids, including seven new ones, were isolated from the whole herb of <i>E. helioscopia</i> L. Compounds <b>1</b> and <b>2</b>, each featuring a 2,3-dicarboxylic functionality, are the first examples in the <i>ent</i>-2,3-<i>sceo</i>-atisane or the <i>ent</i>-2,3-<i>sceo</i>-abietane family. Extensive spectroscopic analysis (1D, 2D NMR, and HRMS data) and computational methods were used to confirm their structures and absolute configurations. According to the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-04-08T18:54:18.079Z","creation":"2025-04-06T16:10:26.763Z"},"accession":"S-EPMC11397010","cross_references":{"pubmed":["39274957"],"doi":["10.3390/molecules29174104"]}}