biostudies-literatureZhao ZZPostdoctoral Research Funding of Henan ProvinceScientific and Technological Key Project in Henan ProvinceNational Natural Science Foundation of Chinathe Scientific and Technological Key Project in Henan ProvinceJoint Fund of Provincial Science and Technology Plan of Henan ProvinceProgram for Innovative Research Team (in Science and Technology) in University of Henan Province4104https://www.ebi.ac.uk/biostudies/studies/S-EPMC11397010biostudies-literatureUnknown29(17)Psoriasis, an immune-mediated inflammatory skin disorder, seriously affects the quality of life of nearly four percent of the world population. <i>Euphorbia helioscopia</i> L. is the monarch constituent of Chinese ZeQi powder preparation for psoriasis, so it is necessary to illustrate its active ingredients. Thus, twenty-three diterpenoids, including seven new ones, were isolated from the whole herb of <i>E. helioscopia</i> L. Compounds <b>1</b> and <b>2</b>, each featuring a 2,3-dicarboxylic functionality, are the first examples in the <i>ent</i>-2,3-<i>sceo</i>-atisane or the <i>ent</i>-2,3-<i>sceo</i>-abietane family. Extensive spectroscopic analysis (1D, 2D NMR, and HRMS data) and computational methods were used to confirm their structures and absolute configurations. According to the Molecules (Basel, Switzerland)Diterpenoids with Potent Anti-Psoriasis Activity from <i>Euphorbia helioscopia</i> L.PMC11397010232102310426 and 2421023103122323014200948200360724IRTSTHN039232102310426242102310312HN2022078He HJSun YJZhao ZZLiang XBXue GMChen HZheng XKZhao YSBian LNFeng WSfalseDiterpenoids with Potent Anti-Psoriasis Activity from <i>Euphorbia helioscopia</i> L.Psoriasis, an immune-mediated inflammatory skin disorder, seriously affects the quality of life of nearly four percent of the world population. <i>Euphorbia helioscopia</i> L. is the monarch constituent of Chinese ZeQi powder preparation for psoriasis, so it is necessary to illustrate its active ingredients. Thus, twenty-three diterpenoids, including seven new ones, were isolated from the whole herb of <i>E. helioscopia</i> L. Compounds <b>1</b> and <b>2</b>, each featuring a 2,3-dicarboxylic functionality, are the first examples in the <i>ent</i>-2,3-<i>sceo</i>-atisane or the <i>ent</i>-2,3-<i>sceo</i>-abietane family. Extensive spectroscopic analysis (1D, 2D NMR, and HRMS data) and computational methods were used to confirm their structures and absolute configurations. According to the 2024-01-01T00:00:00Z2024 Aug2026-04-08T18:54:18.079Z2025-04-06T16:10:26.763ZS-EPMC113970103927495710.3390/molecules29174104