biostudies-literatureUnknown12Xu Y<h4>Background</h4>Although CA19-9 is an essential blood biomarker of pancreatic cancer (PC), its sensitivity and specificity are limited for early detection.<h4>Methods</h4>We analyzed the serum proprotein convertase subtilisin/kexin type 9 (sPCSK9) in PC patients, benign disease groups (BDG), and healthy controls (HC) by ELISA.<h4>Results</h4>Consistently, sPCSK9 was considerably lower in PC patients than in HC (Z = -2.546, <i>P</i> < 0.05), and sPCSK9 in PC patients was statistically significantly higher than in BDG (Z = -5.457, <i>P</i> < 0.001). sPCSK9 was linked to the invasion of lymph nodes (χ² = 6.846, <i>P</i> < 0.01). According to ROC curves, combining sPCSK9 with CA19-9 could potentially enhance the diagnostic capability of CA19-9 in early-stage PC patients. FurthermPeerJe18018https://www.ebi.ac.uk/biostudies/studies/S-EPMC11397121biostudies-literatureSerum PCSK9 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer.PMC11397121Yang YZhang ZXiong QZhu QXu YfalseSerum PCSK9 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer.<h4>Background</h4>Although CA19-9 is an essential blood biomarker of pancreatic cancer (PC), its sensitivity and specificity are limited for early detection.<h4>Methods</h4>We analyzed the serum proprotein convertase subtilisin/kexin type 9 (sPCSK9) in PC patients, benign disease groups (BDG), and healthy controls (HC) by ELISA.<h4>Results</h4>Consistently, sPCSK9 was considerably lower in PC patients than in HC (Z = -2.546, <i>P</i> < 0.05), and sPCSK9 in PC patients was statistically significantly higher than in BDG (Z = -5.457, <i>P</i> < 0.001). sPCSK9 was linked to the invasion of lymph nodes (χ² = 6.846, <i>P</i> < 0.01). According to ROC curves, combining sPCSK9 with CA19-9 could potentially enhance the diagnostic capability of CA19-9 in early-stage PC patients. Furtherm2024-01-01T00:00:00Z20242026-06-03T20:36:51.237Z2025-04-04T00:45:28.004ZS-EPMC113971213928211910.7717/peerj.18018