{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Odent J"],"funding":["French Community of Belgium","European Commission","European Regions Research and Innovation Network"],"pagination":["2502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11398034"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(17)"],"pubmed_abstract":["Diabetes is a major health concern that the next-generation of on-demand insulin releasing implants may overcome via personalized therapy. Therein, 3D-printed phenylboronic acid-containing implants with on-demand glucose-triggered drug release abilities are produced using high resolution stereolithography technology. To that end, the methacrylation of phenylboronic acid is targeted following a two-step reaction. The resulting photocurable phenylboronic acid derivative is accordingly incorporated within bioinert polyhydroxyethyl methacrylate-based hydrogels at varying loadings. The end result is a sub-centimeter scaled 3D-printed bioinert implant that can be remotely activated with 1,2-diols and 1,3-diols such as glucose for on-demand drug administration such as insulin. As a proof of conce"],"journal":["Polymers"],"pubmed_title":["3D-Printed Phenylboronic Acid-Bearing Hydrogels for Glucose-Triggered Drug Release."],"pmcid":["PMC11398034"],"funding_grant_id":["NA","3D4MED"],"pubmed_authors":["Raquez JM","Torcasio SM","Odent J","Coulembier O","Baleine N","Gautier S"],"additional_accession":[]},"is_claimable":false,"name":"3D-Printed Phenylboronic Acid-Bearing Hydrogels for Glucose-Triggered Drug Release.","description":"Diabetes is a major health concern that the next-generation of on-demand insulin releasing implants may overcome via personalized therapy. Therein, 3D-printed phenylboronic acid-containing implants with on-demand glucose-triggered drug release abilities are produced using high resolution stereolithography technology. To that end, the methacrylation of phenylboronic acid is targeted following a two-step reaction. The resulting photocurable phenylboronic acid derivative is accordingly incorporated within bioinert polyhydroxyethyl methacrylate-based hydrogels at varying loadings. The end result is a sub-centimeter scaled 3D-printed bioinert implant that can be remotely activated with 1,2-diols and 1,3-diols such as glucose for on-demand drug administration such as insulin. As a proof of conce","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-19T19:28:51.845Z","creation":"2025-04-19T19:28:51.845Z"},"accession":"S-EPMC11398034","cross_references":{"pubmed":["39274135"],"doi":["10.3390/polym16172502"]}}