biostudies-literatureOdent JFrench Community of BelgiumEuropean CommissionEuropean Regions Research and Innovation Network2502https://www.ebi.ac.uk/biostudies/studies/S-EPMC11398034biostudies-literatureUnknown16(17)Diabetes is a major health concern that the next-generation of on-demand insulin releasing implants may overcome via personalized therapy. Therein, 3D-printed phenylboronic acid-containing implants with on-demand glucose-triggered drug release abilities are produced using high resolution stereolithography technology. To that end, the methacrylation of phenylboronic acid is targeted following a two-step reaction. The resulting photocurable phenylboronic acid derivative is accordingly incorporated within bioinert polyhydroxyethyl methacrylate-based hydrogels at varying loadings. The end result is a sub-centimeter scaled 3D-printed bioinert implant that can be remotely activated with 1,2-diols and 1,3-diols such as glucose for on-demand drug administration such as insulin. As a proof of concePolymers3D-Printed Phenylboronic Acid-Bearing Hydrogels for Glucose-Triggered Drug Release.PMC11398034NA3D4MEDRaquez JMTorcasio SMOdent JCoulembier OBaleine NGautier Sfalse3D-Printed Phenylboronic Acid-Bearing Hydrogels for Glucose-Triggered Drug Release.Diabetes is a major health concern that the next-generation of on-demand insulin releasing implants may overcome via personalized therapy. Therein, 3D-printed phenylboronic acid-containing implants with on-demand glucose-triggered drug release abilities are produced using high resolution stereolithography technology. To that end, the methacrylation of phenylboronic acid is targeted following a two-step reaction. The resulting photocurable phenylboronic acid derivative is accordingly incorporated within bioinert polyhydroxyethyl methacrylate-based hydrogels at varying loadings. The end result is a sub-centimeter scaled 3D-printed bioinert implant that can be remotely activated with 1,2-diols and 1,3-diols such as glucose for on-demand drug administration such as insulin. As a proof of conce2024-01-01T00:00:00Z2024 Sep2025-04-19T19:28:51.845Z2025-04-19T19:28:51.845ZS-EPMC113980343927413510.3390/polym16172502