{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huuki-Myers LA"],"funding":["NIA NIH HHS","NIDA NIH HHS","NIEHS NIH HHS","NIMH NIH HHS","NIGMS NIH HHS"],"pagination":["eadh1938"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11398705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["384(6698)"],"pubmed_abstract":["The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defined spatial domains that move beyond classic cytoarchitecture. We used the Visium spatial gene expression platform to generate a data-driven molecular neuroanatomical atlas across the anterior-posterior axis of the human dorsolateral prefrontal cortex. Integration with paired single-nucleus RNA-sequencing data revealed distinct cell type compositions and cell-cell interactions across spatial domains. Using PsychENCODE and publicly available data, we mapped the enrichment of cell types and genes associated with neuropsychiatric disorders to discrete spatia"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex."],"pmcid":["PMC11398705"],"funding_grant_id":["U01 MH122678","R21 MH105881","R01 MH117406","R56 MH114899","U01 MH122592","P30 AG066514","U01 MH122590","U01 MH122591","R01 MH117291","R21 MH129817","R01 MH105898","R01 MH117293","R01 MH117292","R01 MH126393","R01 MH129301","R01 MH116529","P30 ES010126","U01 MH103365","R21 MH103877","R21 MH105853","R01 MH110905","U01 MH116438","U01 MH122509","R01 MH125516","R56 MH114911","U01 MH116492","U01 MH103339","R21 MH102791","R01 MH111721","R01 MH123183","R01 MH109715","R01 MH109677","R01 MH121521","U01 MH116489","R01 MH105472","U01 MH116487","R01 MH126459","U01 MH116488","U01 MH116441","U01 MH116442","R56 MH114901","U01 MH103346","U01 MH122681","R01 MH110920","R21 MH109956","U01 MH103340","R01 MH110927","R01 MH110928","R01 MH094714","U01 MH103392","R01 MH110926","P50 MH106934","R01 MH110921","U01 DA048279","U01 MH122849","R35 GM139580"],"pubmed_authors":["Gaynor S","Lin X","Ziffra R","Kawaguchi R","Reimonn T","Akbarian S","Therrien K","Ruth M","White KP","Almagro Armenteros JJ","Sudhof T","Davila-Velderrain J","He C","Yap CX","Margolis M","Rozowsky J","Nairn AC","Peters MA","Inoue F","Zeng B","Wylie D","Dursun C","Page SC","Quintero D","Schneider JM","Xu S","Ahituv N","Seyedian A","Henry E","Gerstein M","Champagne FA","Meng R","Wuchty S","Sebra R","Sestan N","Stein J","Nemeroff CB","Pollard KS","Wei Y","Drusinsky S","Qin ZS","Ressler KJ","Snijders C","Sriworarat C","Zintel TM","Phalke N","Bicks L","Ross D","Myers RM","Weimer AK","Jajoo A","Chien JF","Hallmayer J","Bendl J","Kellis M","Wong W","Huuki-Myers LA","Deng C","Hawken N","Pollen A","Micallef C","Pjanic M","Mazariegos S","Snyder M","Tsai LH","Clement A","Crawford GE","DiPietro CP","Chess A","Goes FS","Mukamel EA","Arasappan D","Lou S","Przytycki PF","Gupta C","Vo D","Chen Y","Chatterjee T","Kozlenkov A","Li J","Daskalakis NP","Cooper GM","Kundaje A","Li M","Bharadwaj RA","Steyert M","Kleopoulos SP","Edelstein J","Liu J","Jiang L","Jourdon A","Ma S","Ma L","Subburaju S","Shieh AW","Liu S","Jensen M","Shin JH","Deep-Soboslay A","Ming GL","Jops C","Pattni R","Mariani J","Vaccarino FM","Omberg L","Skarica M","Kleinman JE","Patowary A","Shedd N","Fullard JF","Emani PS","Zhang Y","Hwang A","Kwon SH","Liu C","Zhang J","Maynard KR","Chen HI","Tran MN","Hyde TM","Guo Q","Zhang P","Galani K","PsychENCODE Consortium†","Guo H","Scuderi S","Moore JE","Pertea G","Eagles NJ","Hoffman GE","Jin P","Guo B","Zhang C","Zhang B","Pochareddy S","Zeier ZR","Hadas Y","Jin T","Battle A","Divecha HR","Chu Z","Hicks SC","Ruzicka WB","Ho LL","Nguyen AB","Haroutunian V","Girdhar K","Spangler A","Norton S","van Bakel H","Warrell J","Han X","Cheng Y","Lee D","Montgomery KD","Mohammadi S","Lee C","Shao Z","Greenleaf W","Cheng L","Nowakowski T","Reach S","Montgomery KS","Collado-Torres L","Duong D","Capauto D","Beliveau BJ","Zhou X","Ni P","Chatzinakos C","Wang SH","Huang Y","Dai R","Clarke D","Mikhailova T","Kriegstein A","Dracheva S","Brennand K","Grundman J","Wang D","Moran JR","Grant-Peters M","Wu F","Wu H","Voloudakis G","Wang T","Weng Z","Wen C","Wang Y","Berretta S","Roussos P","Galeev T","Lu D","Monte E","Park S","PsychENCODE Consortium","Pratt H","Ho M","Pinto D","Sanders SJ","Ryten M","Rajagopalan AS","Wamsley B","Whalen S","Martinowich K","State MW","Ravichandran P","Urban AE","Abyzov A","Geschwind DH","Raj T","Willsey AJ","Won H","Iatrou A","Gandal MJ","Tippani M","Song H","Duan Z","Loupe JM","Bhattacharya A","Qu PP","Purmann C","Tao R","Weinberger DR","Seyfried N","Kundu S"],"additional_accession":[]},"is_claimable":false,"name":"A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex.","description":"The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defined spatial domains that move beyond classic cytoarchitecture. We used the Visium spatial gene expression platform to generate a data-driven molecular neuroanatomical atlas across the anterior-posterior axis of the human dorsolateral prefrontal cortex. Integration with paired single-nucleus RNA-sequencing data revealed distinct cell type compositions and cell-cell interactions across spatial domains. Using PsychENCODE and publicly available data, we mapped the enrichment of cell types and genes associated with neuropsychiatric disorders to discrete spatia","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T23:22:10.503Z","creation":"2025-04-04T07:40:56.892Z"},"accession":"S-EPMC11398705","cross_references":{"pubmed":["38781370"],"doi":["10.1126/science.adh1938"]}}