biostudies-literatureJohnson ECBLRD VANCATS NIH HHSNIDA NIH HHSU.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)NIAAA NIH HHSU.S. Department of Health &amp; Human Services | NIH | National Institute on Drug AbuseU.S. Department of Veterans Affairs (Department of Veterans Affairs)U.S. Department of Veterans AffairsGouvernement du Canada | Canadian Institutes of Health ResearchGouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)U.S. Department of Health &amp; Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism1655-1665https://www.ebi.ac.uk/biostudies/studies/S-EPMC11399264biostudies-literatureUnknown49(11)Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are causal, and to what extent shared genetic factors play a role. We explored the relationships between schizophrenia (Scz; European ancestry N = 161,405; African ancestry N = 15,846), cannabis use disorder (CanUD; European ancestry N = 886,025; African ancestry N = 120,208), and ever-regular tobacco smoking (Smk; European ancestry N = 805,431; African ancestry N = 24,278) using the largest available genome-wide studies of these phenotypes in individuals of African and European ancestries. All three phenotypes were positively genetically correlated (r<sub>g<Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyCross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.PMC11399264IK2 BX005058DP1 DA054394R01DA058862K99 AA030808K01DA051759K99AA030808UL1 TR001863Postdoctoral FellowshipCanada Research Chair in Translational NeuropsychopharmacologyR01 DA0588621IK2BX005058-01A2Levey DFThorpe HHADi Forti MEdenberg HJAustin-Zimmerman IDemontis DSanchez-Roige SJohnson ECAgrawal ABaranger DAAGelernter JDavis LKColbert SMCKhokhar JYfalseCross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are causal, and to what extent shared genetic factors play a role. We explored the relationships between schizophrenia (Scz; European ancestry N = 161,405; African ancestry N = 15,846), cannabis use disorder (CanUD; European ancestry N = 886,025; African ancestry N = 120,208), and ever-regular tobacco smoking (Smk; European ancestry N = 805,431; African ancestry N = 24,278) using the largest available genome-wide studies of these phenotypes in individuals of African and European ancestries. All three phenotypes were positively genetically correlated (r<sub>g<2024-01-01T00:00:00Z2024 Oct2026-06-02T23:05:15.907Z2025-04-04T19:38:40.256ZS-EPMC113992643890699110.1038/s41386-024-01886-3