{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bak SM"],"funding":["Korea Institute of Toxicology","National Research Council of Science and Technology"],"pagination":["21433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11399298"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fractions for identifying mutagens and pro-mutagens. However, many substances show completely different toxicity patterns depending on whether the liver S9 fraction belongs to rats or humans. The natural product Polygoni Multiflori Radix (PMR) can also show bacterial reverse mutation, followed by the rat or human liver S9 fraction. While PMR elicits reverse mutations in the TA1537 strain in rat liver S9 but not in human liver S9, this mechanism has not been verified yet. To explain this, the differences in"],"journal":["Scientific reports"],"pubmed_title":["Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system."],"pmcid":["PMC11399298"],"funding_grant_id":["CAP-21023-000","1711195885(KK-2404)"],"pubmed_authors":["Park JH","Jeung NY","Lee BS","Bak SM","Kim NY","Han KH","Kim YB","Kim DY","Back SM","Cho HJ","Park SH","Kim SK","Jung S","Ozden O","Lee HG"],"additional_accession":[]},"is_claimable":false,"name":"Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system.","description":"The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fractions for identifying mutagens and pro-mutagens. However, many substances show completely different toxicity patterns depending on whether the liver S9 fraction belongs to rats or humans. The natural product Polygoni Multiflori Radix (PMR) can also show bacterial reverse mutation, followed by the rat or human liver S9 fraction. While PMR elicits reverse mutations in the TA1537 strain in rat liver S9 but not in human liver S9, this mechanism has not been verified yet. To explain this, the differences in","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-03T00:03:19.181Z","creation":"2025-04-04T08:18:07.95Z"},"accession":"S-EPMC11399298","cross_references":{"pubmed":["39271730"],"doi":["10.1038/s41598-024-72283-5"]}}