{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo Y"],"funding":["China Scholarship Council","Nantong Municipal Science and Technology Bureau"],"pagination":["21410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11399301"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Acute ischemic stroke (AIS) is a major global health concern due to its high mortality and disability rates. Hemorrhagic transformation, a common complication of AIS, leads to poor prognosis yet lacks effective treatments. Preclinical studies indicate that hyperbaric oxygen (HBO) treatment within 12 h of AIS onset alleviates ischemia/reperfusion injuries, including hemorrhagic transformation. However, clinical trials have yielded conflicting results, suggesting some underlying mechanisms remain unclear. In this study, we confirmed that HBO treatments beginning within 1 h post reperfusion significantly alleviated the haemorrhage and neurological deficits in hyperglycemic transient middle cerebral arterial occlusion (tMCAO) mice, partly due to the inhibition of the NLRP3 inflammasome-mediate"],"journal":["Scientific reports"],"pubmed_title":["ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice."],"pmcid":["PMC11399301"],"funding_grant_id":["MS22022058","JCZ21107"],"pubmed_authors":["Xu L","Liu J","Qi M","Guo Y","She T","Du X","Liu Y","Jiang Z","Li X","Peng B","Zhang Y","Xue K","Wu X","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice.","description":"Acute ischemic stroke (AIS) is a major global health concern due to its high mortality and disability rates. Hemorrhagic transformation, a common complication of AIS, leads to poor prognosis yet lacks effective treatments. Preclinical studies indicate that hyperbaric oxygen (HBO) treatment within 12 h of AIS onset alleviates ischemia/reperfusion injuries, including hemorrhagic transformation. However, clinical trials have yielded conflicting results, suggesting some underlying mechanisms remain unclear. In this study, we confirmed that HBO treatments beginning within 1 h post reperfusion significantly alleviated the haemorrhage and neurological deficits in hyperglycemic transient middle cerebral arterial occlusion (tMCAO) mice, partly due to the inhibition of the NLRP3 inflammasome-mediate","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-21T22:19:19.91Z","creation":"2025-04-05T18:43:14.496Z"},"accession":"S-EPMC11399301","cross_references":{"pubmed":["39271781"],"doi":["10.1038/s41598-024-72454-4"]}}