biostudies-literatureIlfeld BMNCATS NIH HHS1325-1331https://www.ebi.ac.uk/biostudies/studies/S-EPMC11399314biostudies-literatureUnknown139(6)<h4>Background</h4>The smallest meaningful improvement in pain scores (minimal clinically important difference [MCID]) after an analgesic intervention is essential information when both interpreting published data and designing a clinical trial. However, limited information is available for patients with chronic pain conditions, and what is published is derived from studies involving pharmacologic and psychological interventions. We here calculate these values based on data collected from 144 participants of a previously published multicenter clinical trial investigating the effects of a single treatment with percutaneous cryoneurolysis.<h4>Methods</h4>In the original trial, we enrolled patients with a lower-limb amputation and established phantom pain. Each received a single-injection femAnesthesia and analgesiaSmallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial.PMC11399314UL1 TR001442Beck GJPadwal JMascha EJSmith CRLiu LEisenach JCIlfeld BMKhan ZTrescot AMJiang QMaheshwari KSessler DIMiller MEGunnett AMMariano ERTuran APrologo JDThaper AHayek SMPAINfRE InvestigatorsWadhwa ANHunt MCohen SPBravo MAli Sakr Esa WAbdullah BFisher RLSalih AAltinpulluk EYHackworth RJBakal OSigmon CGabriel RAMounir-Soliman LfalseSmallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial.<h4>Background</h4>The smallest meaningful improvement in pain scores (minimal clinically important difference [MCID]) after an analgesic intervention is essential information when both interpreting published data and designing a clinical trial. However, limited information is available for patients with chronic pain conditions, and what is published is derived from studies involving pharmacologic and psychological interventions. We here calculate these values based on data collected from 144 participants of a previously published multicenter clinical trial investigating the effects of a single treatment with percutaneous cryoneurolysis.<h4>Methods</h4>In the original trial, we enrolled patients with a lower-limb amputation and established phantom pain. Each received a single-injection fem2024-01-01T00:00:00Z2024 Dec2026-06-06T07:21:52.29Z2026-06-06T03:07:19.159ZS-EPMC113993143847887610.1213/ane.000000000000683310.1213/ANE.0000000000006833