{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Falah G"],"pubmed_abstract":["The Druze are a distinct group known for their close community, traditions, and consanguineous marriages, dating back to the eleventh century. This practice has led to unique genetic variations, impacting both pathology and gene-associated phenotypes. Some Druze clans, particularly those with exceptional long-lived family heads (ELLI), attracted attention. Given that the bulk of these ELLI were men, the d3GHR polymorphism was the first obvious possibility. Among the 73 clan members, 8.2% carried the d3GHR isoform, with nearly 11% being males. There was a significant age-related increase (p = 0.04) in this isoform among males, leading to examination of potential environmental mediators affecting gene regulation among these carriers during life (namely epigenetic). We focused on DNA methylat"],"journal":["Scientific reports"],"pagination":["21419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11399368"],"repository":["biostudies-literature"],"pubmed_title":["The d3GHR carrier epigenome in Druze clan longevity."],"pmcid":["PMC11399368"],"pubmed_authors":["Moustafa N","Falah G","Atzmon G","Paperna T","Amir Y","Kurolap A","Baris Feldman H","Damouny-Naoum N","Sharvit L","Hassoun G","Moghrabi R","Fares F","Ekhilevitch N"],"additional_accession":[]},"is_claimable":false,"name":"The d3GHR carrier epigenome in Druze clan longevity.","description":"The Druze are a distinct group known for their close community, traditions, and consanguineous marriages, dating back to the eleventh century. This practice has led to unique genetic variations, impacting both pathology and gene-associated phenotypes. Some Druze clans, particularly those with exceptional long-lived family heads (ELLI), attracted attention. Given that the bulk of these ELLI were men, the d3GHR polymorphism was the first obvious possibility. Among the 73 clan members, 8.2% carried the d3GHR isoform, with nearly 11% being males. There was a significant age-related increase (p = 0.04) in this isoform among males, leading to examination of potential environmental mediators affecting gene regulation among these carriers during life (namely epigenetic). We focused on DNA methylat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-02T22:19:14.927Z","creation":"2025-04-06T12:29:53.168Z"},"accession":"S-EPMC11399368","cross_references":{"pubmed":["39271799"],"doi":["10.1038/s41598-024-72240-2"]}}