biostudies-literatureUnknown14(1)Falah GThe Druze are a distinct group known for their close community, traditions, and consanguineous marriages, dating back to the eleventh century. This practice has led to unique genetic variations, impacting both pathology and gene-associated phenotypes. Some Druze clans, particularly those with exceptional long-lived family heads (ELLI), attracted attention. Given that the bulk of these ELLI were men, the d3GHR polymorphism was the first obvious possibility. Among the 73 clan members, 8.2% carried the d3GHR isoform, with nearly 11% being males. There was a significant age-related increase (p = 0.04) in this isoform among males, leading to examination of potential environmental mediators affecting gene regulation among these carriers during life (namely epigenetic). We focused on DNA methylatScientific reports21419https://www.ebi.ac.uk/biostudies/studies/S-EPMC11399368biostudies-literatureThe d3GHR carrier epigenome in Druze clan longevity.PMC11399368Moustafa NFalah GAtzmon GPaperna TAmir YKurolap ABaris Feldman HDamouny-Naoum NSharvit LHassoun GMoghrabi RFares FEkhilevitch NfalseThe d3GHR carrier epigenome in Druze clan longevity.The Druze are a distinct group known for their close community, traditions, and consanguineous marriages, dating back to the eleventh century. This practice has led to unique genetic variations, impacting both pathology and gene-associated phenotypes. Some Druze clans, particularly those with exceptional long-lived family heads (ELLI), attracted attention. Given that the bulk of these ELLI were men, the d3GHR polymorphism was the first obvious possibility. Among the 73 clan members, 8.2% carried the d3GHR isoform, with nearly 11% being males. There was a significant age-related increase (p = 0.04) in this isoform among males, leading to examination of potential environmental mediators affecting gene regulation among these carriers during life (namely epigenetic). We focused on DNA methylat2024-01-01T00:00:00Z2024 Sep2026-06-02T22:19:14.927Z2025-04-06T12:29:53.168ZS-EPMC113993683927179910.1038/s41598-024-72240-2