{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["75(2)"],"submitter":["Saito M"],"pubmed_abstract":["Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo."],"journal":["Journal of virology"],"pagination":["1065-71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC114005"],"repository":["biostudies-literature"],"pubmed_title":["In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes."],"pmcid":["PMC114005"],"pubmed_authors":["Osame M","Taylor GP","Bangham CR","Furukawa Y","Weber JN","Saito M","Saito A","Usuku K"],"additional_accession":[]},"is_claimable":false,"name":"In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.","description":"Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo.","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Jan","modification":"2025-04-04T09:52:15.793Z","creation":"2019-03-27T00:17:04Z"},"accession":"S-EPMC114005","cross_references":{"pubmed":["11134322"],"doi":["10.1128/JVI.75.2.1065-1071.2001","10.1128/jvi.75.2.1065-1071.2001"]}}