biostudies-literatureUnknown75(2)Saito MUsing HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo.Journal of virology1065-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC114005biostudies-literatureIn vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.PMC114005Osame MTaylor GPBangham CRFurukawa YWeber JNSaito MSaito AUsuku KfalseIn vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo.2001-01-01T00:00:00Z2001 Jan2025-04-04T09:52:15.793Z2019-03-27T00:17:04ZS-EPMC1140051113432210.1128/JVI.75.2.1065-1071.200110.1128/jvi.75.2.1065-1071.2001